Ageing alters the impact of nutrition on immune function
| العنوان: | Ageing alters the impact of nutrition on immune function |
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| المؤلفون: | Parveen Yaqoob |
| المصدر: | Proceedings of the Nutrition Society. 76:347-351 |
| بيانات النشر: | Cambridge University Press (CUP), 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Societies, Scientific, 0301 basic medicine, Gerontology, Biomedical Research, Dietetics, Immunosenescence, Nutritional Sciences, T-Lymphocytes, Psychological intervention, Medicine (miscellaneous), Adaptive Immunity, Biology, Probiotic, 03 medical and health sciences, 0302 clinical medicine, Immune system, AMPK AMP-activated protein kinase, Immunity, Intervention (counseling), Fatty Acids, Omega-3, Humans, Medical history, Aged, Nutrition, Aged, 80 and over, 2. Zero hunger, Nutrition and Dietetics, Probiotics, Congresses as Topic, Fatty acid, Immunity, Innate, Gastrointestinal Microbiome, 3. Good health, Vaccination, Ageing, 030104 developmental biology, Elder Nutritional Physiological Phenomena, 030220 oncology & carcinogenesis, Chronic Disease, Dietary Supplements, Diet, Healthy |
| الوصف: | Immunosenescence during ageing is a major challenge which weakens the ability of older individuals to respond to infection or vaccination. There has been much interest in dietary strategies to improve immunity in older people, but there is an assumption that modulation of the immune response in older people will be based on the same principles as for younger adults. Recent evidence suggests that ageing fundamentally alters the impact of nutrition on immune function. As a result, interpretation of data from studies investigating the impact of diet on immune function is highly dependent on subject age. Study design is critically important when investigating the efficacy of dietary components, and most studies involving older people include rigorous inclusion/exclusion criteria based on medical history, laboratory tests, general health status and often nutritional status. However, immunological status is rarely accounted for, but can vary significantly, even amongst healthy older people. There are several clear examples of age-related changes in immune cell composition, phenotype and/or function, which can directly alter the outcome of an intervention. This review uses two case studies to illustrate how the effects of n-3 PUFA and probiotics differ markedly in young v. older subjects. Evidence from both suggests that baseline differences in immunosenescence influence the outcome of an intervention, highlighting the need for detailed immunological characterisation of subjects prior to interventions. Finally, future work elucidating alterations in metabolic regulation within cells of the immune system as a result of ageing may be important in understanding the impact of diet on immune function in older people. |
| وصف الملف: | application/pdf |
| تدمد: | 1475-2719 0029-6651 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae894e993e16715c158f4b28a6019e60Test https://doi.org/10.1017/s0029665116000781Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ae894e993e16715c158f4b28a6019e60 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14752719 00296651 |
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