التفاصيل البيبلوغرافية
| العنوان: |
Serotonin 1A receptors in the living brain of Alzheimer's disease patients. |
| المؤلفون: |
Kepe, Vladimir, Barrio, Jorge R., Sung-Cheng Huang, Ercoli, Linda, Siddarth, Prabha, Shoghi-Jadid, Kooresh, Cole, Gregory M., Satyamurthy, Nagichettiar, Cummings, Jeffrey L., Small, Gary W., Phelps, Michael E. |
| المصدر: |
Proceedings of the National Academy of Sciences of the United States of America; 1/17/2006, Vol. 103 Issue 3, p702-707, 6p |
| مصطلحات موضوعية: |
SEROTONIN, ALZHEIMER'S disease, CELL nuclei, TOMOGRAPHY, COMPUTER-aided diagnosis, MEDICAL radiography, AMIDES |
| مستخلص: |
4-[F-18]fluoro-N-(2-[4-(2-methoxyphenyl)-1 -piperazinyl]ethyl)-N-(2- pyridinyl)benzamide, a selective serotonin 1A (5-HT1A) molecular imaging probe, was used in conjunction with positron emission tomography (PET) for quantification of 5-HT1A receptor densities in the living brains of Alzheimer's disease patients (ADs) (n = 8), subjects with mild cognitive impairment (n = 6), and controls (n = 5). ADs had receptor densities significantly decreased in both hippocampi (binding potential: controls 1.62 ± 0.07; ADs 1.18 ± 0.26) and also in raphe nuclei (controls 0.63 ± 0.09; ADs 0.37 ± 0.20). When volume losses are included, 5-HT1A losses are even more severe (i.e., average mean decreases of 24% in mild cognitive impairment patients and 49% in ADs). A strong correlation of 5-HT1A receptor decreases in hippocampus with worsening of clinical symptoms (Mini Mental State Exam scores) was also found. Moreover, these decreases in 5-HT1A receptor measures correlate with decreased glucose utilization as measured with 2-deoxy-2-[F- 18]fluoro-D-glucose PET in the brains of ADs (standardized uptake values; globally: controls 0.89 ± 0.04, ADs 0.72 ± 0.04; posterior cingulate gyrus: controls 1.05 ± 0.09, ADs 0.79 ± 0.11). They also inversely correlate with increased neuropathological loads measured with 2-(1 -(6-[(2-[F-18)fluoroethyl)(methyl)amino]-2-naphthyl)ethylidene)malononitrile PET in several neocortical regions in the same subjects. The in vivo observations were confirmed independently by in vitro digital autoradiography with 4-[F-18]fluoro- N-(2-[4-(2-methoxyphenyl)-1 -piperazinyl]ethyl)-N-(2-pyridinyl)benzamide and 2-(1-(6-[(2-[F-18]fluoroethyl)(methyl)amino]-2-naphthyl)- ethylidene)malononitrile on brain tissue specimens from two ADs and three nondemented subjects. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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