FOXA1 overexpression mediates endocrine resistance by altering the ER transcriptome and IL-8 expression in ER-positive breast cancer
| العنوان: | FOXA1 overexpression mediates endocrine resistance by altering the ER transcriptome and IL-8 expression in ER-positive breast cancer |
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| المؤلفون: | Xiaoyong Fu, Myles Brown, Rachel Schiff, Carolina Gutierrez, Laura M. Heiser, Martin Shea, C. Kent Osborne, Obi L. Griffith, Anna Tsimelzon, Fugen Li, Catherine S. Grasso, Mothaffar F. Rimawi, Pavana Anur, Rinath Jeselsohn, Dolores Lopez-Terrada, Dean P. Edwards, Joe W. Gray, Carmine De Angelis, Emporia F Hollingsworth, Resel Pereira, Susan G. Hilsenbeck, Meghana V. Trivedi, Chad J. Creighton, Agostina Nardone, Paul T. Spellman, Nicholas J. Wang, Shixia Huang |
| المساهمون: | Fu, X., Jeselsohn, R., Pereira, R., Hollingsworth, E. F., Creighton, C. J., Li, F., Shea, M., Nardone, A., De Angelis, C., Heiser, L. M., Anur, P., Wang, N., Grasso, C. S., Spellman, P. T., Griffith, O. L., Tsimelzon, A., Gutierrez, C., Huang, S., Edwards, D. P., Trivedi, M. V., Rimawi, M. F., Lopez-Terrada, D., Hilsenbeck, S. G., Gray, J. W., Brown, M., Osborne, C. K., Schiff, R. |
| المصدر: | Proceedings of the National Academy of Sciences of the United States of America. 113(43) |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Hepatocyte Nuclear Factor 3-alpha, Antineoplastic Agents, Hormonal, Prognosi, Estrogen receptor, Breast Neoplasms, Biology, Transcriptome, 03 medical and health sciences, Breast cancer, Cell Line, Tumor, medicine, Humans, RNA, Small Interfering, Gene knockdown, Multidisciplinary, Pioneer factor, Interleukin-8, Estrogen Receptor alpha, medicine.disease, Prognosis, Survival Analysis, Gene Expression Regulation, Neoplastic, Tamoxifen, 030104 developmental biology, PNAS Plus, Drug Resistance, Neoplasm, Transcriptional reprogramming, Cancer research, Female, Survival Analysi, FOXA1, Estrogen receptor alpha, Breast Neoplasm, Endocrine resistance, Human, medicine.drug, Signal Transduction |
| الوصف: | SignificanceOne of the mechanisms of endocrine resistance in estrogen receptor α (ER)-positive (+) breast cancer is the cross-talk between the ER and growth factor receptor pathways leading to altered ER activity and a reprogrammed ER-dependent transcriptome. However, key mediators of this ER-dependent transcriptional reprogramming remain elusive. Here we demonstrate that forkhead box protein A1 (FOXA1) up-regulation via gene amplification or overexpression contributes to endocrine resistance and increased invasiveness phenotypes by altering the ER-dependent transcriptome. We further show that IL-8, one of the top altered FOXA1/ER effectors, plays a key role in mediating these phenotypes and is a potential target to treat ER+/FOXA1-high breast cancer. Our findings provoke a new interplay of FOXA1 in the ER transcriptional program in endocrine-resistant breast cancer. |
| تدمد: | 1091-6490 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed2387c3c513051ae7743e2ef46a0318Test https://pubmed.ncbi.nlm.nih.gov/27791031Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ed2387c3c513051ae7743e2ef46a0318 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10916490 |
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