المؤلفون: Silvia Corrochano, Abigail Harris, Hans Clevers, Caroline Eozenou, Isabelle Stévant, Joelle Bignon-Topalovic, Nick Warr, Neila Belguith, Sara Wells, Bochra Ben Rhouma, Pam Siggers, Serge Nef, Daniel T. Grimes, Ken McElreavey, Rebecca D. Burdine, Feng Cong, Makoto Suzuki, Andy Greenfield, Danielle Sagar, Anu Bashamboo, Bon-Kyoung Koo, Raja Brauner

المساهمون: Medical Research Coucil Harwell [Oxford, UK] (MRC Harwell), MRC Harwell, Department of Molecular Biology [Princeton], Princeton University, Novartis Institutes for BioMedical Research (NIBR), Hubrecht Institute [Utrecht, Netherlands], University Medical Center [Utrecht]-Royal Netherlands Academy of Arts and Sciences (KNAW), Université de Genève = University of Geneva (UNIGE), Fondation Ophtalmologique Adolphe de Rothschild [Paris], Université Paris Descartes - Paris 5 (UPD5), Faculté de médecine - Faculty of Medicine [Sfax, Tunisie] (FMS), Université de Sfax - University of Sfax, Génétique du Développement humain - Human developmental genetics, Institut Pasteur [Paris] (IP), This work was supported by the Medical Research Council by core funding Grant MC_U142684167 (to A.G.) at the Harwell Institute, and the Agence Nationale de la Recherche Grant ANR-10-LABX-73 (to K.M.). S.N. acknowledges support from Swiss National Science Foundation Grant 31003A_173070. M.S. was a visiting scientist supported by the Strategic International Research Exchange Program between Princeton University and National Institutes of Natural Sciences, Japan. D.T.G. was supported by National Institute of Arthritis and Mucoskeletal and Skin Diseases Pathway to Independence Award 1K99AR070905. Work in the R.D.B. laboratory is supported by the National Institute of Child Health and Development Grant 2R01HD048584., We thank the husbandry team in Ward 5 of the Mary Lyon Centre at Harwell and the Frozen Embryo and Sperm Archive (FESA) and histology teams. We thank Dagmar Wilhelm for the kind gift of anti-FOXL2 antibody. We thank Phil Johnson for zebrafish husbandry. We acknowledge European Cooperation in Science & Technology (COST) Action BM1303 (DSDnet)., ANR-10-LABX-0073,REVIVE,Stem Cells in Regenerative Biology and Medicine(2010), Université de Genève (UNIGE), Génétique du développement humain, Institut Pasteur [Paris], Hubrecht Institute for Developmental Biology and Stem Cell Research

المصدر: Proceedings of the National Academy of Sciences, Vol. 115, No 21 (2018) pp. 5474-5479
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2018, 115 (21), pp.5474-5479. ⟨10.1073/pnas.1801223115⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2018, 115 (21), pp.5474-5479. ⟨10.1073/pnas.1801223115⟩
Proceedings of the National Academy of Sciences of the United States of America, 115(21), 5474
Proceedings of the National Academy of Sciences of the United States of America, 115(21), 5474-5479. National Academy of Sciences

مصطلحات موضوعية: 0301 basic medicine, Male, Embryo, Nonmammalian, Sex Differentiation, Organogenesis, Wnt Proteins/antagonists & inhibitors, Disorders of Sex Development, DSD, MESH: Wnt Proteins / metabolism, MESH: Testis / metabolism, MESH: Disorders of Sex Development / genetics, MESH: Testis / pathology, MESH: Embryo, Nonmammalian / cytology, Mice, Embryo, Nonmammalian/cytology, MESH: Gene Expression Regulation, Developmental, Testis, Missense mutation, MESH: Animals, ddc:576.5, Developmental, Disorders of sex development, 10. No inequality, MESH: Ubiquitin-Protein Ligases / genetics, Exome sequencing, Cells, Cultured, beta Catenin, Zebrafish, Multidisciplinary, Cultured, MESH: Thrombospondins / genetics, MESH: SOX9 Transcription Factor / metabolism, Wnt signaling pathway, Gene Expression Regulation, Developmental, SOX9 Transcription Factor, beta Catenin/antagonists & inhibitors, MESH: beta Catenin / metabolism, Sex reversal, MESH: Gonads / pathology, Cell biology, MESH: Young Adult, Embryo, MESH: Gonads / metabolism, Female, MESH: Cells, Cultured, Adult, Adolescent, Ubiquitin-Protein Ligases, Cells, Thrombospondins/genetics, Mutation, Missense, MESH: beta Catenin / antagonists & inhibitors, SOX9, Biology, Gonads/metabolism, MESH: Embryo, Nonmammalian / metabolism, 03 medical and health sciences, Young Adult, MESH: Wnt Proteins / genetics, WNT signaling, medicine, Animals, Humans, Ubiquitin-Protein Ligases/genetics, MESH: SOX9 Transcription Factor / genetics, MESH: Zebrafish, RSPO1, Gonads, General, MESH: Mice, Nonmammalian/cytology, MESH: Disorders of Sex Development / pathology, MESH: Adolescent, MESH: Wnt Proteins / antagonists & inhibitors, MESH: Mutation, Missense, MESH: Humans, MESH: beta Catenin / genetics, ZNRF3, MESH: Adult, Sex determination, medicine.disease, MESH: Male, MESH: Ubiquitin-Protein Ligases / physiology, SOX9 Transcription Factor/genetics, Wnt Proteins, 030104 developmental biology, MESH: Thrombospondins / metabolism, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, Gene Expression Regulation, Mutation, Testis/metabolism, Missense, Thrombospondins, MESH: Female, Function (biology), Disorders of Sex Development/genetics, MESH: Sex Differentiation

وصف الملف: image/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f785b7c346bbb98027161ca7382405e7Test
https://hdl.handle.net/20.500.11755/a85a814a-a5a7-4064-9ca8-516f15a8bb58Test

المؤلفون: Cedric S. Raine, Cameron Scott, Justin Lengfeld, Claire Choi, Dritan Agalliu, Sarah E. Lutz, Julian R. Smith, Craig M. Walsh, Ilir Agalliu, Claudiu Diaconu, Sigal Kofman

المصدر: Proceedings of the National Academy of Sciences of the United States of America. 114(7)

مصطلحات موضوعية: 0301 basic medicine, CD4-Positive T-Lymphocytes, Central Nervous System, Beta-catenin, Encephalomyelitis, Autoimmune, Experimental, Multiple Sclerosis, Endothelium, Caveolin 1, Mice, Transgenic, Biology, Blood–brain barrier, 03 medical and health sciences, Mice, Congenic, 0302 clinical medicine, medicine, Animals, Humans, Wnt Signaling Pathway, beta Catenin, Multidisciplinary, Tight junction, Experimental autoimmune encephalomyelitis, Wnt signaling pathway, Endothelial Cells, medicine.disease, Cell biology, Endothelial stem cell, Mice, Inbred C57BL, 030104 developmental biology, medicine.anatomical_structure, Transcytosis, PNAS Plus, Blood-Brain Barrier, Immunology, biology.protein, Female, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed7f5e4180d1da3382bad634eb0f32c4Test
https://pubmed.ncbi.nlm.nih.gov/28137846Test

المؤلفون: Tae-Min Kim, Sung Hak Lee, Sug Hyung Lee, Sang Yong Song, Tae In Park, Charles Lee, Seung-Hyun Jung, Hyun Joo Choi, Ki Ouk Min, Yeun-Jun Chung, Min Sung Kim, Ok Ran Shin, Hai-Dong Xu, Hyun-Chun Park, Jeana Kim, Leeso Maeng, Kyo Young Lee, Tae-Jung Kim

المصدر: Proceedings of the National Academy of Sciences of the United States of America. 113(38)

مصطلحات موضوعية: 0301 basic medicine, Pulmonary Sclerosing Hemangioma, Adult, Male, Pathology, medicine.medical_specialty, Stromal cell, Lung Neoplasms, Adolescent, Somatic cell, AKT1, Biology, medicine.disease_cause, Benign tumor, Hemangioma, 03 medical and health sciences, 0302 clinical medicine, Exome Sequencing, medicine, Humans, Exome, Exome sequencing, beta Catenin, Aged, Mutation, Multidisciplinary, Histiocytoma, Benign Fibrous, Genome, Human, Genomics, Middle Aged, Biological Sciences, medicine.disease, 030104 developmental biology, 030220 oncology & carcinogenesis, embryonic structures, Cancer research, Female, Proto-Oncogene Proteins c-akt

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0f1ebdfe14985efc97d91bd8e214225Test
https://pubmed.ncbi.nlm.nih.gov/27601661Test

المؤلفون: Andrea B. Maier, Jeff S. Pawlikowski, Karen Blyth, Mark E. Drotar, John van Tuyn, Ayala King, Hong Wu, Peter D. Adams, Rachael N. Hewitt, Tony McBryan

المساهمون: Internal medicine, MOVE Research Institute, Neuromechanics, AMS - Ageing and Morbidity

المصدر: Pawlikowski, J S, McBryan, T, van Tuyn, J, Drotar, M E, Hewitt, R N, Maier, A B, King, A, Blyth, K, Wu, H & Adams, P D 2013, ' Wnt signaling potentiates nevogenesis ', Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 40, pp. 16009-16014 . https://doi.org/10.1073/pnas.1303491110Test
Proceedings of the National Academy of Sciences of the United States of America, 110(40), 16009-16014. National Academy of Sciences
Pawlikowski, J S, McBryan, T, van Tuyn, J, Drotar, M E, Hewitt, R N, Maier, A B, King, A, Blyth, K, Wu, H & Adams, P D 2013, ' Wnt signaling potentiates nevogenesis ', Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 40, pp. 16009-14 . https://doi.org/10.1073/pnas.1303491110Test
Proceedings of the National Academy of Sciences of the United States of America, 110(40), 16009-14. National Acad Sciences

مصطلحات موضوعية: Senescence, Beta-catenin, Population, Immunoblotting, Biology, Real-Time Polymerase Chain Reaction, Cell Line, Mice, SDG 3 - Good Health and Well-being, Cell Line, Tumor, medicine, Animals, Humans, skin and connective tissue diseases, education, neoplasms, Melanoma, Nevus, Wnt Signaling Pathway, Transcription factor, Cellular Senescence, DNA Primers, education.field_of_study, DNA Primers/genetics, Multidisciplinary, Tumor, Sequence Analysis, RNA, Melanoma/etiology, Wnt signaling pathway, Neural crest, Cellular Senescence/physiology, Biological Sciences, medicine.disease, Microarray Analysis, Immunohistochemistry, Cell biology, HEK293 Cells, biology.protein, Nevus/metabolism, Melanocytes, RNA, Wnt Signaling Pathway/physiology, Cell aging, Melanocytes/cytology, Sequence Analysis

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a287b84fcd3b67c8ab3209b37d7b796cTest
https://doi.org/10.1073/pnas.1303491110Test

المؤلفون: Kenneth J. Pienta, Hong Zhang, Andrew S. Goldstein, Aaron R. Cooper, Justin M. Drake, Donald B. Kohn, Jiaoti Huang, Xian Liu, Tanya Stoyanova, Owen N. Witte, Andrew J. Armstrong

المصدر: Proceedings of the National Academy of Sciences of the United States of America, vol 110, iss 50
Stoyanova, T; Cooper, AR; Drake, JM; Liu, X; Armstrong, AJ; Pienta, KJ; et al.(2013). Prostate cancer originating in basal cells progresses to adenocarcinoma propagated by luminal-like cells. Proceedings of the National Academy of Sciences of the United States of America, 110(50), 20111-20116. doi: 10.1073/pnas.1320565110. UCLA: Retrieved from: http://www.escholarship.org/uc/item/7b54g7bnTest

مصطلحات موضوعية: Male, Aging, Pathology, Basal Cell, Cell Transformation, Basal (phylogenetics), Prostate cancer, Stem Cell Research - Nonembryonic - Human, Neoplasms, 2.1 Biological and endogenous factors, Aetiology, beta Catenin, Cancer, education.field_of_study, Multidisciplinary, biology, medicine.diagnostic_test, Blotting, Prostate Cancer, food and beverages, Biological Sciences, Flow Cytometry, Immunohistochemistry, Gene Expression Regulation, Neoplastic, Cell Transformation, Neoplastic, Phenotype, Adenocarcinoma, Western, Signal Transduction, Urologic Diseases, medicine.medical_specialty, Beta-catenin, Population, Blotting, Western, Flow cytometry, Rare Diseases, Cancer stem cell, Genetics, medicine, Humans, education, Neoplasms, Basal Cell, Neoplastic, fungi, Prostatic Neoplasms, Stem Cell Research, medicine.disease, Eukaryotic Initiation Factor-4E, Gene Expression Regulation, biology.protein, Cancer research

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::136923c2b1ab5f27b2d9a1e3e3d1acefTest
https://pubmed.ncbi.nlm.nih.gov/24282295Test

المؤلفون: Jeffery R. Barrow, Gabriela M Cash, L. Charles Murtaugh, Aaron Smith, Jared J. Barrott

المصدر: Proceedings of the National Academy of Sciences of the United States of America. 108(31)

مصطلحات موضوعية: Male, Mesoderm, Beta-catenin, Blotting, Western, Molecular Sequence Data, Ectoderm, Wnt1 Protein, Biology, TCF/LEF family, Wnt-5a Protein, Wnt3 Protein, Mice, medicine, Animals, Humans, Amino Acid Sequence, Cells, Cultured, beta Catenin, Body Patterning, Mice, Knockout, Multidisciplinary, Wnt signaling pathway, Membrane Proteins, Fibroblasts, Biological Sciences, medicine.disease, Embryo, Mammalian, Molecular biology, Phenotype, Focal dermal hypoplasia, Cell biology, PORCN, Focal Dermal Hypoplasia, Mice, Inbred C57BL, Wnt Proteins, Disease Models, Animal, medicine.anatomical_structure, biology.protein, Female, TCF Transcription Factors, Acyltransferases, Gene Deletion

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2f940ef154ab5f023be93b3a380825cTest
https://pubmed.ncbi.nlm.nih.gov/21768372Test

المؤلفون: Cynthia L. Andoniadou, Nicoletta Charolidi, Mehul T. Dattani, Massimo Signore, Makoto Mark Taketo, Roger Kyeyune, Sujatha A. Jayakody, Paul Le Tissier, Bertrand Vernay, Juan Pedro Martinez-Barbera, Thomas S. Jacques, Carles Gaston-Massuet

المصدر: Proceedings of the National Academy of Sciences of the United States of America. 108(28)

مصطلحات موضوعية: medicine.medical_specialty, Pituitary gland, Beta-catenin, Cellular differentiation, Biology, Pituitary neoplasm, Craniopharyngioma, Mice, Internal medicine, Commentaries, medicine, Animals, Humans, Pituitary Neoplasms, Progenitor cell, beta Catenin, Homeodomain Proteins, Multidisciplinary, Stem Cells, Pituitary tumors, Wnt signaling pathway, Cell Differentiation, medicine.disease, Mice, Mutant Strains, Cell biology, Repressor Proteins, Wnt Proteins, Disease Models, Animal, medicine.anatomical_structure, Endocrinology, Pituitary Gland, biology.protein, Mutant Proteins, Stem cell, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38991b3fdf745505067b578fb3b4f475Test
https://pubmed.ncbi.nlm.nih.gov/21719710Test

المؤلفون: Nick Barker, Xinwei Wang, Lin Zhang, Wataru Yasui, Jian Yu, Wei Qiu, Robert E. Schoen, Brian J. Leibowitz, Hans Clevers, Naohide Oue, Hongtao Liu, Hitoshi Okada

المساهمون: Hubrecht Institute for Developmental Biology and Stem Cell Research

المصدر: Proceedings of the National Academy of Sciences of the United States of America, 107(46), 20027-20032. National Academy of Sciences

مصطلحات موضوعية: Male, Beta-catenin, Time Factors, Adenomatous polyposis coli, Colorectal cancer, Colonic Polyps, Apoptosis, Pharmacology, Chemoprevention, Mitochondrial Proteins, Mice, Sulindac, medicine, Animals, Humans, Phosphorylation, beta Catenin, Aged, Cell Nucleus, Multidisciplinary, biology, Anti-Inflammatory Agents, Non-Steroidal, Wnt signaling pathway, Intracellular Signaling Peptides and Proteins, Middle Aged, Biological Sciences, medicine.disease, digestive system diseases, Intestines, Wnt Proteins, Adenomatous Polyposis Coli, biology.protein, Neoplastic Stem Cells, Female, Signal transduction, Stem cell, Apoptosis Regulatory Proteins, Carrier Proteins, medicine.drug, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d33b3efbbb4fc5c74e9752bd443e458Test
https://pubmed.ncbi.nlm.nih.gov/21041628Test

المؤلفون: Julie L. Prior, Guojun Bu, David Piwnica-Worms, Chia Chen Liu

المصدر: Proceedings of the National Academy of Sciences of the United States of America. 107(11)

مصطلحات موضوعية: Beta-catenin, Cell Survival, Down-Regulation, Breast Neoplasms, medicine.disease_cause, Mice, Breast cancer, Cell Line, Tumor, medicine, Gene silencing, Animals, Humans, RNA, Small Interfering, skin and connective tissue diseases, LDL-Receptor Related Proteins, beta Catenin, Cell Proliferation, Multidisciplinary, biology, Cell growth, Tumor Suppressor Proteins, Wnt signaling pathway, LRP6, LRP5, Biological Sciences, medicine.disease, Xenograft Model Antitumor Assays, Up-Regulation, Gene Expression Regulation, Neoplastic, Wnt Proteins, Gene Knockdown Techniques, Low Density Lipoprotein Receptor-Related Protein-6, Immunology, biology.protein, Cancer research, Female, Carcinogenesis, Molecular Chaperones, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53493d68f4a73b323974feaddc408224Test
https://pubmed.ncbi.nlm.nih.gov/20194742Test

المؤلفون: Dean W. Felsher, Yulin Li, Peter S. Choi

المصدر: Proceedings of the National Academy of Sciences of the United States of America. 111(32)

مصطلحات موضوعية: Lymphoma, medicine.medical_treatment, Mutant, Genes, myc, bcl-X Protein, Apoptosis, Mice, Transgenic, Mice, SCID, Biology, medicine.disease_cause, Targeted therapy, Lesion, Mice, Cell Line, Tumor, Proto-Oncogene Proteins, medicine, Animals, beta Catenin, Mutation, Multidisciplinary, Oncogene, Bcl-2-Like Protein 11, Membrane Proteins, Oncogenes, Oncogene Addiction, medicine.disease, PNAS Plus, Drug Resistance, Neoplasm, Cancer research, RNA Splice Sites, medicine.symptom, Neoplasm Recurrence, Local, Apoptosis Regulatory Proteins

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::386544bfbe59b64291dc4d9eb0f7c117Test
https://pubmed.ncbi.nlm.nih.gov/25071175Test