التفاصيل البيبلوغرافية
| العنوان: |
Modulation of rhythmic brain activity by diazepam: GABAA receptor subtype and state specificity. |
| المؤلفون: |
Kopp, C., Rudolph, U., Löw, K., Tobler, I. |
| المصدر: |
Proceedings of the National Academy of Sciences of the United States of America; 3/9/2004, Vol. 101 Issue 10, p3674-3679, 6p |
| مصطلحات موضوعية: |
DIAZEPAM, NEUROTRANSMITTERS, AMINOBUTYRIC acid, BENZODIAZEPINES, NEUROCHEMISTRY, BUTYRIC acid |
| مستخلص: |
The inhibitory neurotransmitter γ-aminobutyric acid (GABA) is involved in the generation of various brain rhythmic activities that can be modulated by benzodiazepines. Here, we assessed the contribution of &alpah;2GABA type A (GABAA) receptors to the effects of benzodiazepines on sleep and waking oscillatory patterns by combining pharmacological and genetic tools. The effects of diazepam on the electroencephalogram were compared between &alpah;2(H101R) knock-in mice in which the &alpah;2GABAA receptor was rendered diazepam-insensitive, and their wild-type controls. The suppression of delta activity typically induced by diazepam in non-rapid eye movement (REM) sleep was significantly stronger in wild-type control mice than in &alpah;2(H101R) mice. Moreover, electroencephalogram frequency activity above 16-18 Hz was enhanced in wild-type mice both in non-REM sleep and waking. This effect was absent in &alpah;2(H101R) mice. Theta activity was enhanced after diazepam both in REM sleep and in waking in wild-type mice. In &alpah;2(H101R) mice, this effect was markedly reduced in REM sleep whereas it persisted in waking. These findings suggest that &alpah;2GABAA receptors, which are expressed in hypothalamic and pontine nuclei and in the hippocampus, are localized in distinct neural circuits relevant for the modulation of rhythmic brain activities by benzodiazepines. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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