التفاصيل البيبلوغرافية
| العنوان: |
GABA signaling enforces intestinal germinal center B cell differentiation. |
| المؤلفون: |
Yuexia Liao, Lijuan Fan, Peng Bin, Congrui Zhu, Qingyi Chen, Yepeng Cai, Jielin Duan, Qian Cai, Wei Han, Shizhen Ding, Xiangyu Hu, Yiran Zhang, Yulong Yin, Wenkai Ren |
| المصدر: |
Proceedings of the National Academy of Sciences of the United States of America; 11/1/2022, Vol. 119 Issue 44, p1-11, 44p |
| مصطلحات موضوعية: |
B cell differentiation, GERMINAL centers, GABA, B cells, BUTYRIC acid |
| مستخلص: |
Recent compelling results indicate possible links between neurotransmitters, intestinal mucosal IgA+ B cell responses, and immunoglobulin A nephropathy (IgAN) pathogenesis. Here, we demonstrated that γ-amino butyric acid (GABA) transporter-2 (GAT-2) deficiency induces intestinal germinal center (GC) B cell differentiation and worsens the symptoms of IgAN in a mouse model. Mechanistically, GAT-2 deficiency enhances GC B cell differentiation through activation of GABA-mammalian target of rapamycin complex 1 (mTORC1) signaling. In addition, IgAN patients have lower GAT-2 expression but higher activation of mTORC1 in blood B cells, and both are correlated with kidney function in IgAN patients. Collectively, this study describes GABA signaling-mediated intestinal mucosal immunity as a previously unstudied pathogenesis mechanism of IgAN and challenges the current paradigms of IgAN. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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