CD1d-restricted T cells regulate dendritic cell function and antitumor immunity in a granulocyte–macrophage colony-stimulating factor-dependent fashion
| العنوان: | CD1d-restricted T cells regulate dendritic cell function and antitumor immunity in a granulocyte–macrophage colony-stimulating factor-dependent fashion |
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| المؤلفون: | Masaru Taniguchi, Richard S. Blumberg, Silke Gillessen, Edward E. S. Nieuwenhuis, Yuri N. Naumov, Glenn Dranoff, Mark A. Exley, Nicolas Mach, Jack L. Strominger, Andrew D. Luster, S. Brian Wilson, Frederick S. Lee, Steven P. Balk |
| المصدر: | Proceedings of the National Academy of Sciences. 100:8874-8879 |
| بيانات النشر: | Proceedings of the National Academy of Sciences, 2003. |
| سنة النشر: | 2003 |
| مصطلحات موضوعية: | medicine.medical_treatment, Chemokine CXCL2, Melanoma, Experimental, Gene Expression, chemical and pharmacologic phenomena, In Vitro Techniques, Cancer Vaccines, Antigens, CD1, Mice, Interleukin 21, T-Lymphocyte Subsets, medicine, Animals, Cytotoxic T cell, IL-2 receptor, Mice, Knockout, Immunity, Cellular, Multidisciplinary, biology, Granulocyte-Macrophage Colony-Stimulating Factor, hemic and immune systems, Dendritic Cells, Dendritic cell, Biological Sciences, Natural killer T cell, Cell biology, carbohydrates (lipids), Killer Cells, Natural, Mice, Inbred C57BL, Granulocyte macrophage colony-stimulating factor, Cytokine, CD1D, biology.protein, Female, lipids (amino acids, peptides, and proteins), Antigens, CD1d, Chemokines, medicine.drug |
| الوصف: | CD1d-restricted T cells contribute to tumor protection, but their precise roles remain unclear. Here we show that tumor cells engineered to secrete granulocyte–macrophage colony-stimulating factor induce the expansion of CD1d-restricted T cells through a mechanism that involves CD1d and macrophage inflammatory protein 2 expression by CD8α–, CD11c+dendritic cells (DCs). The antitumor immunity stimulated by vaccination with irradiated, granulocyte-macrophage colony-stimulating factor-secreting tumor cells was abrogated in CD1d- and Jα281-deficient mice, revealing a critical role for CD1d-restricted T cells in this response. The loss of antitumor immunity was associated with impaired tumorinduced T helper 2 cytokine production, although IFN-γ secretion and cytotoxicity were preserved. DCs from immunized CD1d-deficient mice showed compromised maturation and function. Together, these results delineate a role for CD1d-restricted T cell–DC cross talk in the shaping of antitumor immunity. |
| تدمد: | 1091-6490 0027-8424 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eef4e2c0e1c9f144ae1c0dfe94942977Test https://doi.org/10.1073/pnas.1033098100Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....eef4e2c0e1c9f144ae1c0dfe94942977 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10916490 00278424 |
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