Intrinsic connectivity networks in healthy subjects explain clinical variability in Alzheimer’s disease
| العنوان: | Intrinsic connectivity networks in healthy subjects explain clinical variability in Alzheimer’s disease |
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| المؤلفون: | William J. Jagust, Bruce L. Miller, Maria Luisa Gorno-Tempini, Cindee Madison, Manja Lehmann, Joel H. Kramer, Gil D. Rabinovici, Michael D. Greicius, Elizabeth C. Mormino, Pia Ghosh, William W. Seeley |
| المصدر: | Proceedings of the National Academy of Sciences of the United States of America, vol 110, iss 28 |
| بيانات النشر: | Proceedings of the National Academy of Sciences, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Male, Aging, Nerve net, Precuneus, Neurodegenerative, Alzheimer's Disease, Cohort Studies, Primary progressive aphasia, Atrophy, Alzheimer Disease, Reference Values, Clinical Research, Task Performance and Analysis, Aphasia, Acquired Cognitive Impairment, medicine, Humans, 2.1 Biological and endogenous factors, Aetiology, Default mode network, Aged, Multidisciplinary, Neurosciences, Brain, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Posterior cortical atrophy, Human brain, Biological Sciences, Middle Aged, medicine.disease, Brain Disorders, medicine.anatomical_structure, Neurological, Female, Dementia, Nerve Net, Alzheimer's disease, Psychology, Neuroscience |
| الوصف: | Although previous studies have emphasized the vulnerability of the default mode network (DMN) in Alzheimer’s disease (AD), little is known about the involvement of other functional networks and their relationship to clinical phenotype. To test whether clinicoanatomic heterogeneity in AD is driven by the involvement of specific networks, network connectivity was assessed in healthy subjects by seeding regions commonly and specifically atrophied in three clinical AD variants: early-onset AD (age at onset |
| وصف الملف: | application/pdf |
| تدمد: | 1091-6490 0027-8424 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce9f3c91fbafe6370dfe43fb3b360907Test https://doi.org/10.1073/pnas.1221536110Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ce9f3c91fbafe6370dfe43fb3b360907 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10916490 00278424 |
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