Circadian patterns of gene expression in the human brain and disruption in major depressive disorder
| العنوان: | Circadian patterns of gene expression in the human brain and disruption in major depressive disorder |
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| المؤلفون: | Prabhakara V. Choudary, David M. Walsh, Fan Meng, Jack D. Barchas, Preston M. Cartagena, Simon J. Evans, Huda Akil, Blynn G. Bunney, Richard M. Myers, Edward G. Jones, Jun Li, William E. Bunney, Alan F. Schatzberg, Megan Hastings Hagenauer, Marquis P. Vawter, Stanley J. Watson |
| المصدر: | Proceedings of the National Academy of Sciences. 110:9950-9955 |
| بيانات النشر: | Proceedings of the National Academy of Sciences, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Circadian clock, Biology, Circadian Clocks, Internal medicine, Basic Helix-Loop-Helix Transcription Factors, medicine, Humans, Circadian rhythm, Aged, Oligonucleotide Array Sequence Analysis, Homeodomain Proteins, Depressive Disorder, Major, Multidisciplinary, Suprachiasmatic nucleus, Gene Expression Profiling, ARNTL Transcription Factors, Brain, Period Circadian Proteins, Human brain, Middle Aged, Biological Sciences, Circadian Rhythm, CLOCK, ARNTL, Dorsolateral prefrontal cortex, medicine.anatomical_structure, Endocrinology, Nuclear Receptor Subfamily 1, Group D, Member 1, Female, Autopsy, Neuroscience |
| الوصف: | A cardinal symptom of major depressive disorder (MDD) is the disruption of circadian patterns. However, to date, there is no direct evidence of circadian clock dysregulation in the brains of patients who have MDD. Circadian rhythmicity of gene expression has been observed in animals and peripheral human tissues, but its presence and variability in the human brain were difficult to characterize. Here, we applied time-of-death analysis to gene expression data from high-quality postmortem brains, examining 24-h cyclic patterns in six cortical and limbic regions of 55 subjects with no history of psychiatric or neurological illnesses (“controls”) and 34 patients with MDD. Our dataset covered ∼12,000 transcripts in the dorsolateral prefrontal cortex, anterior cingulate cortex, hippocampus, amygdala, nucleus accumbens, and cerebellum. Several hundred transcripts in each region showed 24-h cyclic patterns in controls, and >100 transcripts exhibited consistent rhythmicity and phase synchrony across regions. Among the top-ranked rhythmic genes were the canonical clock genes BMAL1(ARNTL), PER1-2-3, NR1D1(REV-ERBa), DBP, BHLHE40 (DEC1) , and BHLHE41(DEC2) . The phasing of known circadian genes was consistent with data derived from other diurnal mammals. Cyclic patterns were much weaker in the brains of patients with MDD due to shifted peak timing and potentially disrupted phase relationships between individual circadian genes. This transcriptome-wide analysis of the human brain demonstrates a rhythmic rise and fall of gene expression in regions outside of the suprachiasmatic nucleus in control subjects. The description of its breakdown in MDD suggests potentially important molecular targets for treatment of mood disorders. |
| تدمد: | 1091-6490 0027-8424 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ed0be26897600b3e57a38e14f15decbTest https://doi.org/10.1073/pnas.1305814110Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4ed0be26897600b3e57a38e14f15decb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10916490 00278424 |
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