Dysregulation of the fibroblast growth factor system in major depression
| العنوان: | Dysregulation of the fibroblast growth factor system in major depression |
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| المؤلفون: | Edward G. Jones, D. M. Walsh, William E. Bunney, Fan Meng, Juan F. Lopez, Hiroaki Tomita, Simon J. Evans, Richard M. Myers, John D.H. Stead, Huda Akil, Robert C. Thompson, Jun Li, S.J. Watson, Marquis P. Vawter, Charles R. Neal, Prabhakara V. Choudary |
| المصدر: | Proceedings of the National Academy of Sciences. 101:15506-15511 |
| بيانات النشر: | Proceedings of the National Academy of Sciences, 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Serotonin reuptake inhibitor, In situ hybridization, Biology, Fibroblast growth factor, Polymerase Chain Reaction, behavioral disciplines and activities, Growth factor receptor, Internal medicine, mental disorders, Gene expression, medicine, Humans, In Situ Hybridization, Aged, Oligonucleotide Array Sequence Analysis, Aged, 80 and over, Depressive Disorder, Major, Multidisciplinary, Microarray analysis techniques, Biological Sciences, Middle Aged, medicine.disease, Fibroblast Growth Factors, Endocrinology, Mechanism of action, Major depressive disorder, Female, medicine.symptom, Selective Serotonin Reuptake Inhibitors |
| الوصف: | In this report we describe findings that imply dysregulation of several fibroblast growth factor (FGF) system transcripts in frontal cortical regions of brains from human subjects with major depressive disorder (MDD). This altered gene expression was discovered by microarray analysis of frontal cortical tissue from MDD, bipolar, and nonpsychiatric control subjects and was verified by quantitative real-time PCR analysis and, importantly, in a separate cohort of MDD subjects. Furthermore, we show, through a separate analysis of specific serotonin reuptake inhibitor (SSRI)-treated and non-SSRI-treated MDD subjects that the observed changes in expression of FGF transcripts are not secondary to drug treatment. Rather, changes in specific FGF transcripts are attenuated by SSRIs and may thus be partially responsible for the mechanism of action of these drugs. We also make available the gene-expression profile of all of the other growth factors and growth factor receptors detected in these postmortem samples. |
| تدمد: | 1091-6490 0027-8424 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e4a9c37bc37a9d0771e810395187cdaTest https://doi.org/10.1073/pnas.0406788101Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4e4a9c37bc37a9d0771e810395187cda |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10916490 00278424 |
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