التفاصيل البيبلوغرافية
| العنوان: |
Failure Mode and Effects Analysis for Experimental Use of FLASH on a Clinical Accelerator. |
| المؤلفون: |
Rahman, Mahbubur, Zhang, Rongxiao, Gladstone, David J., Williams, Benjamin B., Chen, Erli, Dexter, Chad A., Thompson, Lawrence, Bruza, Petr, Pogue, Brian W. |
| المصدر: |
Practical Radiation Oncology; Mar2023, Vol. 13 Issue 2, p153-165, 13p |
| مستخلص: |
The use of a linear accelerator (LINAC) in ultrahigh-dose-rate (UHDR) mode can provide a conduit for wider access to UHDR FLASH effects, sparing normal tissue, but care needs to be taken in the use of such systems to ensure errors are minimized. The failure mode and effects analysis was carried out in a team that has been involved in converting a LINAC between clinical use and UHDR experimental mode for more than 1 year after the proposed methods of TG100. A team of 9 professionals with extensive experience were polled to outline the process map and workflow for analysis, and developed fault trees for potential errors, as well as failure modes that would result. The team scored the categories of severity magnitude, occurrence likelihood, and detectability potential in a scale of 1 to 10, so that a risk priority number (RPN = severity×occurrence×detectability) could be assessed for each. A total of 46 potential failure modes were identified, including 5 with an RPN >100. These failure modes involved (1) patient set up, (2) gating mechanisms in delivery, and (3) detector in the beam stop mechanism. The identified methods to mitigate errors included the (1) use of a checklist post conversion, (2) use of robust radiation detectors, (3) automation of quality assurance and beam consistency checks, and (4) implementation of surface guidance during beam delivery. The failure mode and effects analysis process was considered critically important in this setting of a new use of a LINAC, and the expert team developed a higher level of confidence in the ability to safely move UHDR LINAC use toward expanded research access. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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