دورية أكاديمية
Altered β-Cell Prohormone Processing and Secretion in Type 1 Diabetes
العنوان: | Altered β-Cell Prohormone Processing and Secretion in Type 1 Diabetes |
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المؤلفون: | Rodriguez-Calvo, Teresa, Chen, Yi-Chun, Verchere, C. Bruce, Haataja, Leena, Arvan, Peter, Leete, Pia, Richardson, Sarah J., Morgan, Noel G., Qian, Wei-Jun, Pugliese, Alberto, Atkinson, Mark, Evans-Molina, Carmella, Sims, Emily K. |
المساهمون: | Pediatrics, School of Medicine |
المصدر: | PMC |
بيانات النشر: | American Diabetes Association |
سنة النشر: | 2021 |
المجموعة: | Indiana University - Purdue University Indianapolis: IUPUI Scholar Works |
مصطلحات موضوعية: | Type 1 diabetes mellitus, Insulin-secreting cells, Proinsulin |
الوصف: | Analysis of data from clinical cohorts, and more recently from human pancreatic tissue, indicates that reduced prohormone processing is an early and persistent finding in type 1 diabetes. In this article, we review the current state of knowledge regarding alterations in islet prohormone expression and processing in type 1 diabetes and consider the clinical impact of these findings. Lingering questions, including pathologic etiologies and consequences of altered prohormone expression and secretion in type 1 diabetes, and the natural history of circulating prohormone production in health and disease, are considered. Finally, key next steps required to move forward in this area are outlined, including longitudinal testing of relevant clinical populations, studies that probe the genetics of altered prohormone processing, the need for combined functional and histologic testing of human pancreatic tissues, continued interrogation of the intersection between prohormone processing and autoimmunity, and optimal approaches for analysis. Successful resolution of these questions may offer the potential to use altered prohormone processing as a biomarker to inform therapeutic strategies aimed at personalized intervention during the natural history of type 1 diabetes and as a pathogenic anchor for identification of potential disease-specific endotypes. |
نوع الوثيقة: | article in journal/newspaper |
وصف الملف: | application/pdf |
اللغة: | English |
العلاقة: | Diabetes; Rodriguez-Calvo T, Chen YC, Verchere CB, et al. Altered β-Cell Prohormone Processing and Secretion in Type 1 Diabetes. Diabetes. 2021;70(5):1038-1050. doi:10.2337/dbi20-0034; https://hdl.handle.net/1805/33988Test |
الإتاحة: | https://doi.org/10.2337/dbi20-0034Test https://hdl.handle.net/1805/33988Test |
حقوق: | Publisher Policy |
رقم الانضمام: | edsbas.96D6FA81 |
قاعدة البيانات: | BASE |
الوصف غير متاح. |