المؤلفون: Johnson, Jared L., Yaron, Tomer M., Huntsman, Emily M., Kerelsky, Alexander, Song, Junho, Regev, Amit, Lin, Ting-Yu, Liberatore, Katarina, Cizin, Daniel M., Cohen, Benjamin M., Vasan, Neil, Ma, Yilun, Krismer, Konstantin, Torres Robles, Jaylissa, van de Kooij, Bert, van Vlimmeren, Anne E., Andrée-Busch, Nicole, Käufer, Norbert F., Dorovkov, Maxim V., Ryazanov, Alexey G., Takagi, Yuichiro, Kastenhuber, Edward R., Goncalves, Marcus D., Hopkins, Benjamin D., Elemento, Olivier, Taatjes, Dylan J., Maucuer, Alexandre, Yamashita, Akio, Degterev, Alexei, Uduman, Mohamed, Lu, Jingyi, Landry, Sean D., Zhang, Bin, Cossentino, Ian, Linding, Rune, Blenis, John, Hornbeck, Peter V., Turk, Benjamin E., Yaffe, Michael B., Cantley, Lewis C.

المساهمون: Biochemistry and Molecular Biology, School of Medicine

المصدر: PMC

مصطلحات موضوعية: Kinases, Cellular signalling networks, Bioinformatics, Phosphorylation

وصف الملف: application/pdf

العلاقة: Nature; Johnson JL, Yaron TM, Huntsman EM, et al. An atlas of substrate specificities for the human serine/threonine kinome. Nature. 2023;613(7945):759-766. doi:10.1038/s41586-022-05575-3; https://hdl.handle.net/1805/36481Test

الإتاحة: https://doi.org/10.1038/s41586-022-05575-3Test
https://hdl.handle.net/1805/36481Test

المؤلفون: Murphy, Charles J., Karreth, Florian A., Elemento, Olivier, Toker, Alex, Wulf, Gerburg M., Cantley, Lewis C., Yang, Kangkang, Liu, Hui, Emdal, Kristina Bennet, Cantley, Lewis C, White, Forest M.

المساهمون: Massachusetts Institute of Technology. Department of Biological Engineering, Massachusetts Institute of Technology. Department of Biology, Koch Institute for Integrative Cancer Research at MIT, Liu, Hui, Emdal, Kristina Bennet, White, Forest M, Cantley, Lewis C

المصدر: PMC

وصف الملف: application/pdf

العلاقة: http://dx.doi.org/10.1158/2159-8290.CD-17-0679Test; Cancer Discovery; http://hdl.handle.net/1721.1/121024Test; Liu, Hui, Charles J. Murphy, Florian A. Karreth, Kristina B. Emdal, Forest M. White, Olivier Elemento, Alex Toker, Gerburg M. Wulf, and Lewis C. Cantley. “Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple-Negative Breast Cancer.” Cancer Discovery 8, no. 3 (December 4, 2017): 354–369.; orcid:0000-0001-6483-9110; orcid:0000-0002-1545-1651

الإتاحة: https://doi.org/10.1158/2159-8290.CD-17-0679Test
http://hdl.handle.net/1721.1/121024Test

المؤلفون: Wang, Ying-Hua, Lee, Dongjun, Yu, Vionnie W.C., Jeanson, Nathaniel T., Clish, Clary B., Cantley, Lewis C., Scadden, David T., Israelsen, William James, Vander Heiden, Matthew G.

المساهمون: Massachusetts Institute of Technology. Department of Biology, Koch Institute for Integrative Cancer Research at MIT, Israelsen, William James, Vander Heiden, Matthew G.

المصدر: PMC

وصف الملف: application/pdf

العلاقة: http://dx.doi.org/10.1016/j.cell.2014.07.048Test; Cell; http://hdl.handle.net/1721.1/105820Test; Wang, Ying-Hua et al. “Cell-State-Specific Metabolic Dependency in Hematopoiesis and Leukemogenesis.” Cell 158.6 (2014): 1309–1323.; orcid:0000-0002-6702-4192

الإتاحة: https://doi.org/10.1016/j.cell.2014.07.048Test
http://hdl.handle.net/1721.1/105820Test

المؤلفون: Li, Jie, Sasaki, Mika, Horner, James W., Burga, Laura N., Xie, Jianxin, Jurczak, Michael J., DePinho, Ronald A., Clish, Clary B., Kibbey, Richard G., Wulf, Gerburg M., Di Vizio, Dolores, Mills, Gordon B., Cantley, Lewis C., Israelsen, William James, Dayton, Talya L., Davidson, Shawn M., Fiske, Brian Prescott, Hosios, Aaron Marc, Bellinger, Gary, Yu, Yimin, Jacks, Tyler E., Vander Heiden, Matthew G.

المساهمون: Massachusetts Institute of Technology. Department of Biology, Koch Institute for Integrative Cancer Research at MIT, Israelsen, William James, Dayton, Talya L., Davidson, Shawn M., Fiske, Brian Prescott, Hosios, Aaron Marc, Bellinger, Gary, Yu, Yimin, Jacks, Tyler E., Vander Heiden, Matthew G.

المصدر: PMC

وصف الملف: application/pdf

العلاقة: http://dx.doi.org/10.1016/j.cell.2013.09.025Test; Cell; http://hdl.handle.net/1721.1/110601Test; Israelsen, William J. et al. “PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells.” Cell 155.2 (2013): 397–409.; orcid:0000-0002-7994-7963; orcid:0000-0002-7702-5877; orcid:0000-0001-5785-8911; orcid:0000-0002-6702-4192

الإتاحة: https://doi.org/10.1016/j.cell.2013.09.025Test
http://hdl.handle.net/1721.1/110601Test

المؤلفون: Fendt, Sarah-Maria, Bell, Eric L., Keibler, Mark Andrew, Davidson, Shawn Michael, Wirth, Gregory J., Fiske, Brian Prescott, Mayers, Jared R., Schwab, Matthias, Bellinger, Gary, Csibi, Alfred, Patnaik, Akash, Blouin, Marie Jose, Cantley, Lewis C., Guarente, Leonard Pershing, Blenis, John, Pollak, Michael N., Olumi, Aria F., Vander Heiden, Matthew G., Stephanopoulos, Gregory

المساهمون: Massachusetts Institute of Technology. Department of Biology, Massachusetts Institute of Technology. Department of Chemical Engineering, Koch Institute for Integrative Cancer Research at MIT, Fendt, Sarah-Maria, Bell, Eric L., Keibler, Mark Andrew, Davidson, Shawn Michael, Fiske, Brian Prescott, Mayers, Jared R., Guarente, Leonard Pershing, Vander Heiden, Matthew G., Stephanopoulos, Gregory

المصدر: PMC

وصف الملف: application/pdf

العلاقة: http://dx.doi.org/10.1158/0008-5472.can-13-0080Test; Cancer Research; http://hdl.handle.net/1721.1/91508Test; Fendt, S.-M., E. L. Bell, M. A. Keibler, S. M. Davidson, G. J. Wirth, B. Fiske, J. R. Mayers, et al. “Metformin Decreases Glucose Oxidation and Increases the Dependency of Prostate Cancer Cells on Reductive Glutamine Metabolism.” Cancer Research 73, no. 14 (May 17, 2013): 4429–4438.; orcid:0000-0002-8607-1787; orcid:0000-0002-6702-4192; orcid:0000-0002-5410-6543; orcid:0000-0003-4064-2510; orcid:0000-0001-6909-4568; orcid:0000-0003-0701-5275

الإتاحة: https://doi.org/10.1158/0008-5472.can-13-0080Test
http://hdl.handle.net/1721.1/91508Test

المؤلفون: Walsh, Martin J., Brimacombe, Kyle R., Veith, Henrike, Bougie, James M., Daniel, Thomas, Leister, William, Cantley, Lewis C., Vander Heiden, Matthew G., Shen, Min, Auld, Douglas S., Thomas, Craig J., Boxer, Matthew B., Israelsen, William James

المساهمون: Massachusetts Institute of Technology. Department of Biology, Koch Institute for Integrative Cancer Research at MIT, Israelsen, William J., Vander Heiden, Matthew G.

المصدر: PMC

وصف الملف: application/pdf

العلاقة: http://dx.doi.org/10.1016/j.bmcl.2011.08.114Test; Bioorganic & Medicinal Chemistry Letters; http://hdl.handle.net/1721.1/99178Test; Walsh, Martin J., Kyle R. Brimacombe, Henrike Veith, James M. Bougie, Thomas Daniel, William Leister, Lewis C. Cantley, et al. “2-Oxo-N-Aryl-1,2,3,4-Tetrahydroquinoline-6-Sulfonamides as Activators of the Tumor Cell Specific M2 Isoform of Pyruvate Kinase.” Bioorganic & Medicinal Chemistry Letters 21, no. 21 (November 2011): 6322–6327.; orcid:0000-0002-6702-4192

الإتاحة: https://doi.org/10.1016/j.bmcl.2011.08.114Test
http://hdl.handle.net/1721.1/99178Test

المؤلفون: Taniguchi, Cullen M., Winnay, Jonathon, Kondo, Tatsuya, Bronson, Roderick T., Guimaraes, Alexander R., Aleman, Jose O., Luo, Ji, Stephanopoulos, Gregory, Weissleder, Ralph, Cantley, Lewis C., Kahn, C. Ronald

المساهمون: Massachusetts Institute of Technology. Department of Chemical Engineering, Stephanopoulos, Gregory, Aleman, Jose O.

المصدر: PMC

وصف الملف: application/pdf

العلاقة: http://dx.doi.org/10.1158/0008-5472.CAN-09-3399Test; Cancer Research; http://hdl.handle.net/1721.1/79358Test; Taniguchi, C. M., J. Winnay, T. Kondo, R. T. Bronson, A. R. Guimaraes, J. O. Aleman, J. Luo, et al. The Phosphoinositide 3-Kinase Regulatory Subunit p85 Can Exert Tumor Suppressor Properties Through Negative Regulation of Growth Factor Signaling. Cancer Research 70, no. 13 (June 30, 2010): 5305-5315.; orcid:0000-0001-6909-4568

الإتاحة: https://doi.org/10.1158/0008-5472.CAN-09-3399Test
http://hdl.handle.net/1721.1/79358Test

المؤلفون: Vander Heiden, Matthew G., Locasale, Jason W., Swanson, Kenneth D., Sharfi, Hadar, Heffron, Gregory J., Amador-Noguez, Daniel, Christofk, Heather R., Wagner, Gerhard, Rabinowitz, Joshua D., Asara, John M., Cantley, Lewis C.

المساهمون: Massachusetts Institute of Technology. Department of Biology, Koch Institute for Integrative Cancer Research at MIT, Vander Heiden, Matthew G.

المصدر: PMC

وصف الملف: application/pdf

العلاقة: http://dx.doi.org/10.1126/science.1188015Test; Science; http://hdl.handle.net/1721.1/85108Test; Vander Heiden, Matthew G., Jason W. Locasale, Kenneth D. Swanson, Hadar Sharfi, Greg J. Heffron, Daniel Amador-Noguez, Heather R. Christofk, Gerhard Wagner, Joshua D. Rabinowitz, John M. Asara, and Lewis C. Cantley. "Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells." Science 17 September 2010: 329 (5998), 1492-1499.; orcid:0000-0002-6702-4192

الإتاحة: https://doi.org/10.1126/science.1188015Test
http://hdl.handle.net/1721.1/85108Test