التفاصيل البيبلوغرافية
| العنوان: |
Effectiveness of shengxuexiaoban capsules combined with glucocorticoid therapy for immune thrombocytopenia: A meta-analysis. |
| المؤلفون: |
Ding, Meng-Yuan, Li, Bing, Yang, Meng, Zhai, Wen-Sheng, Song, Chun-Dong, Zhang, Jian, Zhang, Qiu-Yue, Li, Peng-Fei, Liu, Li-Ya |
| المصدر: |
PLoS ONE; 9/30/2022, Vol. 17 Issue 9, p1-12, 12p |
| مصطلحات موضوعية: |
IDIOPATHIC thrombocytopenic purpura, GLUCOCORTICOIDS, THROMBOPOIETIN receptors, BLOOD platelets, PLATELET count, RANDOMIZED controlled trials, PUBLICATION bias |
| مستخلص: |
Objective: To evaluate the effectiveness of the Shengxuexiaoban Capsules combined with glucocorticoid therapy for immune thrombocytopenia (ITP). Methods: We collected randomized controlled trials (RCTs) using shengxuexiaoban capsules in combination with glucocorticoid to treat ITP by searching major Chinese and English electronic databases. The outcome indicators were the effective rate, recurrence rate, the number of platelets in the blood, recovery time of platelets, and adverse reactions. We used STATA 16.0 and RevMan 5.3 for meta-analysis and GRADE pro. for evidence quality evaluation. Results: A total of 27 RCTs were included in the meta-analysis, and the results showed a significant difference (all p<0.05) in the effective rate, recurrence rate, the number of platelets, and the recovery time of platelets (≥ 100×109) between ITP patients in the control group (who received glucocorticoid therapy alone) and test group (who received glucocorticoid therapy combined with the Shengxuexiaoban Capsules). And that Shengxuexiaoban capsules combined with glucocorticoid therapy were safe. The funnel plot and Egger's test results indicated no obvious publication bias. The GRADE evidence rating showed an intermediate quality of evidence rating for recurrence rate and overall effectiveness. Conclusion: Glucocorticoid therapy combined with the Shengxuexiaoban Capsules showed more effectiveness in the treatment of ITP. It can improve the effective rate, reduce the recurrence rate, increase the number of platelets and shorten the recovery time of platelets, and has a good safety profile. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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