التفاصيل البيبلوغرافية
| العنوان: |
Primary Localization and Tumor Thickness as Prognostic Factors of Survival in Patients with Mucosal Melanoma. |
| المؤلفون: |
Mehra, Tarun, Grözinger, Gerd, Mann, Steven, Guenova, Emmanuella, Moos, Rudolf, Röcken, Martin, Claussen, Claus Detlef, Dummer, Reinhard, Clasen, Stephan, Naumann, Aline, Garbe, Claus |
| المصدر: |
PLoS ONE; Nov2014, Vol. 9 Issue 11, p1-10, 10p |
| مصطلحات موضوعية: |
MELANOMA prognosis, MUCOUS membranes, VULVAR cancer, EPIDEMIOLOGY of cancer, MEDICAL statistics |
| مستخلص: |
Background: Data on survival with mucosal melanoma and on prognostic factors of are scarce. It is still unclear if the disease course allows for mucosal melanoma to be treated as primary cutaneous melanoma or if differences in overall survival patterns require adapted therapeutic approaches. Furthermore, this investigation is the first to present 10-year survival rates for mucosal melanomas of different anatomical localizations. Methodology: 116 cases from Sep 10 1984 until Feb 15 2011 retrieved from the Comprehensive Cancer Center and of the Central Register of the German Dermatologic Society databases in Tübingen were included in our analysis. We recorded anatomical location and tumor thickness, and estimated overall survival at 2, 5 and 10 years and the mean overall survival time. Survival times were analyzed with the Kaplan-Meier method. The log-rank test was used to compare survival times by localizations and by T-stages. Principal Findings: We found a median overall survival time of 80.9 months, with an overall 2-year survival of 71.7%, 5-year survival of 55.8% and 10-year survival of 38.3%. The 10-year survival rates for patients with T1, T2, T3 or T4 stage tumors were 100.0%, 77.9%, 66.3% and 10.6% respectively. 10-year survival of patients with melanomas of the vulva was 64.5% in comparison to 22.3% of patients with non-vulva mucosal melanomas. Conclusion: Survival times differed significantly between patients with melanomas of the vulva compared to the rest (p = 0.0006). It also depends on T-stage at the time of diagnosis (p<0.0001). [ABSTRACT FROM AUTHOR] |
|
Copyright of PLoS ONE is the property of Public Library of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder