The density of parasympathetic axons is reduced in the exocrine pancreas of individuals recently diagnosed with type 1 diabetes
| العنوان: | The density of parasympathetic axons is reduced in the exocrine pancreas of individuals recently diagnosed with type 1 diabetes |
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| المؤلفون: | Lundberg, Marcus, Lindqvist, Andreas, Wierup, Nils, Krogvold, Lars, Dahl-Jorgensen, Knut, Skog, Oskar |
| المصدر: | PLOS ONE. 12(6) |
| الوصف: | To elucidate the etiology of type 1 diabetes, the affected pancreas needs to be thoroughly characterized. Pancreatic innervation has been suggested to be involved in the pathology of the disease and a reduction of sympathetic innervation of the islets was recently reported. In the present study, we hypothesized that parasympathetic innervation would be altered in the type 1 diabetes pancreas. Human pancreatic specimens were obtained from a unique cohort of individuals with recent onset or long standing type 1 diabetes. Density of parasympathetic axons was assessed by immunofluorescence and morphometry. Our main finding was a reduced density of parasympathetic axons in the exocrine, but not endocrine compartment of the pancreas in individuals with recent onset type 1 diabetes. The reduced density of parasympathetic axons in the exocrine compartment could have functional implications, e.g. be related to the exocrine insufficiency reported in type 1 diabetes patients. Further studies are needed to understand whether reduced parasympathetic innervation is a cause or consequence of type 1 diabetes. |
| وصف الملف: | electronic |
| الوصول الحر: | https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-330731Test https://doi.org/10.1371/journal.pone.0179911Test https://uu.diva-portal.org/smash/get/diva2:1148197/FULLTEXT01.pdfTest |
| قاعدة البيانات: | SwePub |
| DOI: | 10.1371/journal.pone.0179911 |
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