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1دورية أكاديمية
المؤلفون: Mianqing Wang, Hua He, Xi Fang, Hui Li
المصدر: PLoS ONE, Vol 19, Iss 6 (2024)
وصف الملف: electronic resource
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2دورية أكاديمية
المؤلفون: Lin Zhang, Wenyuan Liu, Sufen Li, Jinjing Wang, Dalin Sun, Hui Li, Ziyuan Zhang, Yaling Hu, Jingai Fang
المصدر: PLoS ONE, Vol 19, Iss 5, p e0304365 (2024)
الوصف: ObjectiveTo explore the molecular mechanism of Astragaloside IV (AS-IV) in alleviating renal fibrosis by inhibiting Urotensin II-induced pyroptosis and epithelial-mesenchymal transition of renal tubular epithelial cells.MethodsForty SD rats were randomly divided into control group without operation: gavage with 5ml/kg/d water for injection and UUO model group: gavage with 5ml/kg/d water for injection; UUO+ AS-IV group (gavage with AS-IV 20mg/kg/d; and UUO+ losartan potassium group (gavage with losartan potassium 10.3mg/kg/d, with 10 rats in each group. After 2 weeks, Kidney pathology, serum Urotensin II, and cAMP concentration were detected, and the expressions of NLRP3, GSDMD-N, Caspase-1, and IL-1β were detected by immunohistochemistry. Rat renal tubular epithelial cells were cultured in vitro, and different concentrations of Urotensin II were used to intervene for 24h and 48h. Cell proliferation activity was detected using the CCK8 assay. Suitable concentrations of Urotensin II and intervention time were selected, and Urotensin II receptor antagonist (SB-611812), inhibitor of PKA(H-89), and AS-IV (15ug/ml) were simultaneously administered. After 24 hours, cells and cell supernatants from each group were collected. The cAMP concentration was detected using the ELISA kit, and the expression of PKA, α-SMA, FN, IL-1β, NLRP3, GSDMD-N, and Caspase-1 was detected using cell immunofluorescence, Western blotting, and RT-PCR.ResultsRenal tissue of UUO rats showed renal interstitial infiltration, tubule dilation and atrophy, renal interstitial collagen fiber hyperplasia, and serum Urotensin II and cAMP concentrations were significantly higher than those in the sham operation group (p ConclusionAS-IV can alleviate renal fibrosis by inhibiting Urotensin II-induced pyroptosis of renal tubular epithelial cells by regulating the cAMP/PKA signaling pathway.
وصف الملف: electronic resource
العلاقة: https://doaj.org/toc/1932-6203Test
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3دورية أكاديمية
المؤلفون: Mingjin Xun, Zhong Feng, Hui Li, Meicun Yao, Haibo Wang, Ruixia Wei, Junwei Jia, Zimao Fan, Xiaoyan Shi, Zhanzhu Lv, Guimin Zhang
المصدر: PLoS ONE, Vol 19, Iss 4, p e0300696 (2024)
الوصف: The primary treatment method for eradicating Helicobacter pylori (H. pylori) infection involves the use of antibiotic-based therapies. Due to the growing antibiotic resistance of H. pylori, there has been a surge of interest in exploring alternative therapies. Cetylpyridinium chloride (CPC) is a water-soluble and nonvolatile quaternary ammonium compound with exceptional broad-spectrum antibacterial properties. To date, there is no documented or described specific antibacterial action of CPC against H. pylori. Therefore, this study aimed to explore the in vitro activity of CPC against H. pylori and its potential antibacterial mechanism. CPC exhibited significant in vitro activity against H. pylori, with MICs ranging from 0.16 to 0.62 μg/mL and MBCs ranging from 0.31 to 1.24 μg/mL. CPC could result in morphological and physiological modifications in H. pylori, leading to the suppression of virulence and adherence genes expression, including flaA, flaB, babB, alpA, alpB, ureE, and ureF, and inhibition of urease activity. CPC has demonstrated in vitro activity against H. pylori by inhibiting its growth, inducing damage to the bacterial structure, reducing virulence and adherence factors expression, and inhibiting urease activity.
وصف الملف: electronic resource
العلاقة: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0300696&type=printableTest; https://doaj.org/toc/1932-6203Test
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4دورية أكاديمية
المؤلفون: Xinjie Sun, Zhifang Liu, Hui Li, Feng Ying, Yu Tao
المصدر: PLoS ONE, Vol 19, Iss 3, p e0295331 (2024)
الوصف: English text has a clear and compact subject structure, which makes it easy to find dependency relationships between words. However, Chinese text often conveys information using situational settings, which results in loose sentence structures, and even most Chinese comments and experimental summary texts lack subjects. This makes it challenging to determine the dependency relationship between words in Chinese text, especially in aspect-level sentiment recognition. To solve this problem faced by Chinese text in the field of sentiment recognition, a Chinese text dual attention network for aspect-level sentiment recognition is proposed. First, Chinese syntactic dependency is proposed, and sentiment dictionary is introduced to quickly and accurately extract aspect-level sentiment words, opinion extraction and classification of sentimental trends in text. Additionally, in order to extract context-level features, the CNN-BILSTM model and position coding are also introduced. Finally, to better extract fine-grained aspect-level sentiment, a two-level attention mechanism is used. Compared with ten advanced baseline models, the model's capabilities are being further optimized for better performance, with Accuracy of 0.9180, 0.9080 and 0.8380 respectively. This method is being demonstrated by a vast array of experiments to achieve higher performance in aspect-level sentiment recognition in less time, and ablation experiments demonstrate the importance of each module of the model.
وصف الملف: electronic resource
العلاقة: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0295331&type=printableTest; https://doaj.org/toc/1932-6203Test
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5دورية أكاديمية
المؤلفون: Qiang Li, Baoshan Chen, Hezhong Yuan, Hui Li, Shunyao Zhuang
المصدر: PLoS ONE, Vol 19, Iss 1 (2024)
وصف الملف: electronic resource
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6دورية أكاديمية
المؤلفون: Hui Li, Quanwei Zhao, Danan Liu, Bo Zhou, Fujun Liao, Long Chen
المصدر: PLoS ONE, Vol 19, Iss 1 (2024)
وصف الملف: electronic resource
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7دورية أكاديمية
المؤلفون: Li Wang, Guangxiao Fan, Qiao Wang, Hui Li, Junhai Huo, Shibo Wei, Qunfeng Niu
المصدر: PLoS ONE, Vol 18, Iss 11 (2023)
وصف الملف: electronic resource
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8دورية أكاديمية
المؤلفون: Hui Li
المصدر: PLoS ONE, Vol 18, Iss 10, p e0288072 (2023)
الوصف: The impact of digital financial inclusion (If) and agricultural technology innovation (Gi) on agricultural carbon emissions has attracted wide attention from the academic community, but the inconsistent conclusions of existing studies and the reality that few studies have gathered them into a framework require more evidence to fill this gap, which can contribute more insights to promoting economic development and controlling carbon emissions. Taking the provincial-level relevant data of China's agriculture from 2011 to 2020 as a sample, the GMM method is used to integrally test the relationship between the three factors. The results show that (1) from 2011 to 2020, China's overall agricultural carbon emissions experienced two stages of fluctuating rise (2011-2015) and continuous decline (2015-2020). In 2015, China's agricultural carbon emissions peaked at 1,040 million tons; Overall, Hunan, Hubei, and Henan were the provinces with the largest agricultural carbon emissions; Beijing, Tianjin, and Shanghai are provinces with relatively low agricultural carbon emissions. (2) Although the impact of digital financial inclusion on agricultural carbon emissions is negative, it is not significant. (3) Agricultural technology innovation promoted the reduction of agricultural carbon emissions. If the level of agricultural technology innovation increased by 1 percentage point, agricultural carbon emissions would decrease by 0.09 percentage points. (4) Mechanism analysis showed that agricultural technology innovation could reduce carbon emissions through the efficiency of agricultural resource allocation, and its effect reached 56%. The results can provide a scientific basis for the government to formulate targeted policies, and the methods can be extended to other places.
وصف الملف: electronic resource
العلاقة: https://doaj.org/toc/1932-6203Test
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9دورية أكاديمية
المؤلفون: Jing Guo, Xianjun Zhu, Wenfeng Li, Hui Li
المصدر: PLoS ONE, Vol 18, Iss 9, p e0291349 (2023)
الوصف: As an essential part of classical analysis, Ostrowski and Čebyšev type inequalities have recently attracted considerable attention. Due to its universality, the non-additive integral inequality takes several forms, including Sugeno integrals, Choquet integrals, and pseudo-integrals. Set-valued analysis, a well-known generalization of classical analysis, is frequently employed in studying mathematical economics, control theory, etc. Inspired by pioneering work on interval-valued inequalities, this paper establishes specific Ostrowski and Čebyšev type inequalities for interval-valued functions. Moreover, the error estimation to quadrature rules is presented as some applications for illustrating our results. In addition, illustrative examples are offered to demonstrate the applicability of the mathematical methods presented.
وصف الملف: electronic resource
العلاقة: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0291349&type=printableTest; https://doaj.org/toc/1932-6203Test
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10دورية أكاديمية
المؤلفون: Yuqi Wu, Yijie Fu, Yuanqiong He, Xinru Gong, Zhoutong Han, Hongli Fan, Tianmin Zhu, Hui Li
المصدر: PLoS ONE, Vol 18, Iss 9, p e0291835 (2023)
الوصف: ObjectivesEnhanced recovery after surgery (ERAS) has become extensively practiced and has shown encouraging benefits. Within recent years, ERAS has also been increasingly performed in chronic rhinosinusitis (CRS) patients undergoing endoscopic sinus surgery (ESS). However, the actual efficacy of ERAS in CRS patients undergoing ESS is not completely clear, and the related evidence remains weak. This systematic review and meta-analysis aimed to evaluate the effectiveness and safety of ERAS in the perioperative management of CRS patients receiving ESS.MethodsWe searched randomized controlled trials in PubMed, Web of Science, EMBASE, Cochrane CENTRAL, Ovid, China National Knowledge Infrastructure, Chinese BioMedical Literature Database, Wanfang, and VIP Database up to February 2023, to analyze the effectiveness and safety of ERAS in ESS perioperative management of CRS patients. We appraised the methodological quality in the included RCTs using the Cochrane Collaboration tool and assessed the quality of evidence with the Recommendations Assessment, Development and Evaluation (GRADE) tool. Meta-analysis, subgroup analysis, and sensitivity analysis were carried out with the the software Review Manager 5.3 and Stata 12.0. In addition, potential publication bias was detected by Begg's test, Egger's test, and funnel plot test.ResultsTwenty-eight studies involving 2636 patients were included within this study. In comparison with the standard care (SC) group, the ERAS group had the advantages in the following aspects: length of stay (MD = -2.50, 95%CI: -3.04 to -1.97), pain scores (MD = -1.07, 95%CI: -1.46 to -0.67), anxiety score (SMD = -2.13, 95%CI: -2.83 to -1.44), depression score (SMD = -2.42, 95%CI: -3.13 to -1.71), hospitalization expenses, and quality of life. At the same time, the ERAS group presented a markedly lower incidence of adverse events in comparison to the SC group, such as overall complications (RR = 0.28, 95%CI:0.20 to 0.41), postoperative nausea and vomiting (RR = 0.33, 95%CI:0.21 to 0.50), facial edema (RR = 0.20, 95%CI:0.11 to 0.38), low back pain (RR = 0.28, 95%CI:0.16 to 0.49), urinary retention (RR = 0.12, 95%CI:0.05 to 0.30) and haemorrhage (RR = 0.19, 95%CI:0.07 to 0.55).ConclusionsThe results showed that the ERAS protocol is effective and safe in CRS patients who undergo ESS. However, Due to the limited overall methodological quality included studies, caution should be exercised in the interpretation of the results. More high-quality, multiple-centre, and large-sample studies are in demand in the future to further validate its clinical efficacy.
وصف الملف: electronic resource
العلاقة: https://doaj.org/toc/1932-6203Test
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