التفاصيل البيبلوغرافية
| العنوان: |
Genome-Wide Association Study of d-Amphetamine Response in Healthy Volunteers Identifies Putative Associations, Including Cadherin 13 ( CDH13). |
| المؤلفون: |
Hart, Amy B.1, Engelhardt, Barbara E.1,2, Wardle, Margaret C.3, Sokoloff, Greta1, Stephens, Matthew1,4, de Wit, Harriet3, Palmer, Abraham A.1,3 |
| المصدر: |
PLoS ONE. Aug2012, Vol. 7 Issue 8, Special section p1-10. 10p. |
| مصطلحات موضوعية: |
*RETINA, *PHOTORECEPTORS, *MELANOPSIN, *RETINAL ganglion cells, *DOPAMINERGIC neurons, *GLUTAMATE receptors |
| مستخلص: |
The canonical flow of visual signals proceeds from outer to inner retina (photoreceptors→bipolar cells →ganglion cells). However, melanopsin- expressing ganglion cells are photosensitive and functional sustained light signaling to retinal dopaminergic interneurons persists in the absence of rods and cones. Here we show that the sustained-type light response of retinal dopamine neurons requires melanopsin and that the response is mediated by AMPA- type glutamate receptors, defining a retrograde retinal visual signaling pathway that fully reverses the usual flow of light signals in retinal circuits. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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