دورية أكاديمية
Effect of calcitriol on bone turnover and osteocalcin in recent-onset type 1 diabetes.
| العنوان: | Effect of calcitriol on bone turnover and osteocalcin in recent-onset type 1 diabetes. |
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| المؤلفون: | Nicola Napoli, Rocky Strollo, Dario Pitocco, Carla Bizzarri, Ernesto Maddaloni, Daria Maggi, Silvia Manfrini, Ann Schwartz, Paolo Pozzilli, IMDIAB Group |
| المصدر: | PLoS ONE, Vol 8, Iss 2, p e56488 (2013) |
| بيانات النشر: | Public Library of Science (PLoS), 2013. |
| سنة النشر: | 2013 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | BackgroundVitamin D supplementation in childhood improves the achievement of peak bone mass. We investigated the effect of supplementation with calcitriol on bone turnover in recent-onset type 1 diabetes (T1D). Moreover, the association between osteocalcin and parameters of β-cell function and metabolic control was examined.Methodology/principal findingsWe conducted a post-hoc analysis of a double-blind, placebo-controlled study of calcitriol supplementation to preserve β-cell function. 27 recent-onset T1D subjects, mean age 22 years, were randomized to 0.25 µg calcitriol per day or placebo (1:1) and followed up for one year. Changes in bone formation (osteoclacin) and resorption (beta-CrossLaps) markers, and differences between placebo and calcitriol-treated group were evaluated. At baseline, osteocalcin levels were significantly lower in female than in male patients (PConclusionsSupplementation with 0.25 µg calcitriol per day to patients with new-onset T1D does not affect circulating markers of bone turnover. OC levels were unrelated to β-cell function and other metabolic parameters suggesting that OC is ineffective to control pancreatic function in presence of aggressive autoimmune destruction. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1932-6203 |
| العلاقة: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23437144/?tool=EBITest; https://doaj.org/toc/1932-6203Test |
| DOI: | 10.1371/journal.pone.0056488 |
| الوصول الحر: | https://doaj.org/article/1e1eb7bbd7b6481b9dbfcb3d2031e405Test |
| رقم الانضمام: | edsdoj.1e1eb7bbd7b6481b9dbfcb3d2031e405 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0056488 |