Molecular detection of human T-lymphotropic virus type 1 infection among oncology patients in Germany: A retrospective view
| العنوان: | Molecular detection of human T-lymphotropic virus type 1 infection among oncology patients in Germany: A retrospective view |
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| المؤلفون: | Ruggieri, Matias, Berini, Carolina, Ducasa, Nicolas, Malkovsky, Miroslav, Fisch, Paul, Biglione, Mirna |
| المصدر: | PLoS ONE CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET PLoS ONE, Vol 14, Iss 5, p e0217560 (2019) |
| بيانات النشر: | Public Library of Science, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | RNA viruses, Male, Physiology, viruses, Ciencias de la Salud, Artificial Gene Amplification and Extension, Blood Donors, Pathology and Laboratory Medicine, Polymerase Chain Reaction, Geographical locations, Hematologic Cancers and Related Disorders, White Blood Cells, immune system diseases, Animal Cells, hemic and lymphatic diseases, Germany, Medicine and Health Sciences, Leukemia-Lymphoma, Adult T-Cell, DNA extraction, Human T-lymphotropic virus 1, T Cells, virus diseases, Hematology, Middle Aged, Paraparesis, Tropical Spastic, Body Fluids, Europe, PCR, Blood, Oncology, Medical Microbiology, Viral Pathogens, Viruses, Medicine, GERMANY, purl.org/becyt/ford/3 [https], Lymphomas, Female, Pathogens, Cellular Types, Anatomy, Research Article, Adult, CIENCIAS MÉDICAS Y DE LA SALUD, Science, Immune Cells, Immunology, Research and Analysis Methods, Microbiology, purl.org/becyt/ford/3.3 [https], Extraction techniques, Diagnostic Medicine, Retroviruses, PATIENTS, Cancer Detection and Diagnosis, Humans, European Union, Molecular Biology Techniques, Microbial Pathogens, Molecular Biology, Retrospective Studies, Blood Cells, Biology and life sciences, Organisms, Cancers and Neoplasms, Htlv-1, Cell Biology, HTLV, Enfermedades Infecciosas, People and places |
| الوصف: | Human T-cell lymphotropic virus (HTLV) belongs to a larger group of primate T-cell lymphotropic viruses (PTLVs) within the family Retroviridae. It is estimated that 10 to 20 million people worldwide may be infected with HTLV-1. Although most of them are asymptomatic, around 5% of infected individuals may develop either HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) or Adult T-cell Leukaemia/Lymphoma (ATLL). Public Health authorities in many countries have implemented routine blood-donor tests for HTLVspecific antibodies; but this is not the case for Germany since the reported prevalence is very low (7/100,000). With the aim to evaluate retrospectively the presence of HTLV-1 among oncology patients in this country, samples stored at the Universitä tsklinikum Freiburg, were analyzed. For this purpose, two different nested-PCR (n-PCR) protocols have been modified and set up for HTLV-1 detection. One positive case was detected by n-PCR among 406 samples (0,25%) in a period of 5 years (2008-2012) corresponding to a T-Cell Lymphoma. Despite the low prevalence, this virus is circulating in Germany, probably due to the increasing numbers of immigrants in these last years. Physicians should consider HTLV-1 infection and suspect it taking in account the ethnic and relation to endemic regions regardless the patient´s residence. Fil: Ruggieri, Matias. Albert Ludwigs University of Freiburg; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina Fil: Berini, Carolina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina Fil: Ducasa, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina Fil: Malkovsky, Miroslav. University of Wisconsin; Estados Unidos Fil: Fisch, Paul. Albert Ludwigs University of Freiburg; Alemania Fil: Biglione, Mirna Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8380459fbe564c23f913c6ad1e5bd99fTest http://europepmc.org/articles/PMC6538170Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.pmid.dedup....8380459fbe564c23f913c6ad1e5bd99f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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