Swiss Transplant Cohort Study (STCS), University of Zurich, Mueller, Nicolas J
المصدر:
PLoS ONE, Vol 13, Iss 1, p e0191167 (2018) PloS one, vol. 13, no. 1, pp. e0191167 PLOS ONE, Vol. 13, No 1 (2018) P. e0191167 PLoS ONE Schreiber, Peter W; Bischoff-Ferrari, Heike A; Boggian, Katia; Bonani, Marco; van Delden, Christian; Enriquez, Natalia; Fehr, Thomas; Garzoni, Christian; Hirsch, Hans H; Hirzel, Cédric; Manuel, Oriol; Meylan, Pascal; Saleh, Lanja; Weisser, Maja; Mueller, Nicolas J (2018). Bone metabolism dynamics in the early post-transplant period following kidney and liver transplantation. PLoS ONE, 13(1), e0191167. Public Library of Science 10.1371/journal.pone.0191167 <http://dx.doi.org/10.1371/journal.pone.0191167Test>
Bone disease contributes to relevant morbidity after solid organ transplantation. Vitamin D has a crucial role for bone metabolism. Activation of vitamin D depends on the endocrine function of both, liver and kidney. Our study assessed key markers of bone metabolism at time of transplantation and 6 months after transplantation among 70 kidney and 70 liver recipients. In 70 kidney recipients 25-OH vitamin D levels did not differ significantly between peri-transplant (median 32.5nmol/l) and 6 months post-transplant (median 41.9nmol/l; P = 0.272). Six months post-transplant median 1, 25-(OH)2 vitamin D levels increased by >300% (from 9.1 to 36.5ng/l; P
