Unique Microstructural Changes in the Brain Associated with Urological Chronic Pelvic Pain Syndrome (UCPPS) Revealed by Diffusion Tensor MRI, Super-Resolution Track Density Imaging, and Statistical Parameter Mapping: A MAPP Network Neuroimaging Study
| العنوان: | Unique Microstructural Changes in the Brain Associated with Urological Chronic Pelvic Pain Syndrome (UCPPS) Revealed by Diffusion Tensor MRI, Super-Resolution Track Density Imaging, and Statistical Parameter Mapping: A MAPP Network Neuroimaging Study |
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| المؤلفون: | Davis Woodworth, Emeran Mayer, Kevin Leu, Cody Ashe-McNalley, Bruce D Naliboff, Jennifer S Labus, Kirsten Tillisch, Jason J Kutch, Melissa A Farmer, A Vania Apkarian, Kevin A Johnson, Sean C Mackey, Timothy J Ness, J Richard Landis, Georg Deutsch, Richard E Harris, Daniel J Clauw, Chris Mullins, Benjamin M Ellingson, MAPP Research Network |
| المساهمون: | He, Huiguang |
| المصدر: | Woodworth, D; Mayer, E; Leu, K; Ashe-McNalley, C; Naliboff, BD; Labus, JS; et al.(2015). Unique microstructural changes in the brain associated with urological chronic pelvic pain syndrome (UCPPS) revealed by diffusion tensor MRI, super-resolution track density imaging, and statistical parameter mapping: A MAPP network neuroimaging study. PLoS ONE, 10(10). doi: 10.1371/journal.pone.0140250. UCLA: Retrieved from: http://www.escholarship.org/uc/item/94d3z61dTest PLoS ONE, Vol 10, Iss 10, p e0140250 (2015) PloS one, vol 10, iss 10 PLoS ONE |
| بيانات النشر: | Public Library of Science (PLoS), 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Male, Pathology, 030232 urology & nephrology, lcsh:Medicine, MAPP Research Network, Gastroenterology, Irritable Bowel Syndrome, 0302 clinical medicine, 2.1 Biological and endogenous factors, Aetiology, lcsh:Science, Irritable bowel syndrome, Sex Characteristics, education.field_of_study, Multidisciplinary, Pain Research, Chronic pain, Brain, Interstitial cystitis, Neurological, Biomedical Imaging, Female, Chronic Pain, medicine.symptom, Research Article, Adult, Urologic Diseases, medicine.medical_specialty, General Science & Technology, Population, Prostatitis, Neuroimaging, Pelvic Pain, 03 medical and health sciences, Clinical Research, Internal medicine, Fractional anisotropy, medicine, Humans, education, business.industry, Pelvic pain, lcsh:R, Neurosciences, medicine.disease, Gastrointestinal Pain, Diffusion Magnetic Resonance Imaging, Case-Control Studies, Anisotropy, lcsh:Q, business, 030217 neurology & neurosurgery |
| الوصف: | Studies have suggested chronic pain syndromes are associated with neural reorganization in specific regions associated with perception, processing, and integration of pain. Urological chronic pelvic pain syndrome (UCPPS) represents a collection of pain syndromes characterized by pelvic pain, namely Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) and Interstitial Cystitis/Painful Bladder Syndrome (IC/PBS), that are both poorly understood in their pathophysiology, and treated ineffectively. We hypothesized patients with UCPPS may have microstructural differences in the brain compared with healthy control subjects (HCs), as well as patients with irritable bowel syndrome (IBS), a common gastrointestinal pain disorder. In the current study we performed population-based voxel-wise DTI and super-resolution track density imaging (TDI) in a large, two-center sample of phenotyped patients from the multicenter cohort with UCPPS (N = 45), IBS (N = 39), and HCs (N = 56) as part of the MAPP Research Network. Compared with HCs, UCPPS patients had lower fractional anisotropy (FA), lower generalized anisotropy (GA), lower track density, and higher mean diffusivity (MD) in brain regions commonly associated with perception and integration of pain information. Results also showed significant differences in specific anatomical regions in UCPPS patients when compared with IBS patients, consistent with microstructural alterations specific to UCPPS. While IBS patients showed clear sex related differences in FA, MD, GA, and track density consistent with previous reports, few such differences were observed in UCPPS patients. Heat maps illustrating the correlation between specific regions of interest and various pain and urinary symptom scores showed clustering of significant associations along the cortico-basal ganglia-thalamic-cortical loop associated with pain integration, modulation, and perception. Together, results suggest patients with UCPPS have extensive microstructural differences within the brain, many specific to syndrome UCPPS versus IBS, that appear to be localized to regions associated with perception and integration of sensory information and pain modulation, and seem to be a consequence of longstanding pain. |
| وصف الملف: | application/pdf |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c0ba53a5e2ab915b6aea2012e7365a5Test https://doi.org/10.1371/journal.pone.0140250Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4c0ba53a5e2ab915b6aea2012e7365a5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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