Possible clinical effects of molecular hydrogen (H2) delivery during hemodialysis in chronic dialysis patients: Interim analysis in a 12 month observation
| العنوان: | Possible clinical effects of molecular hydrogen (H2) delivery during hemodialysis in chronic dialysis patients: Interim analysis in a 12 month observation |
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| المؤلفون: | Shigeru Kabayama, Sadayoshi Ito, Kazumasa Tsunoda, Yukio Maruyama, Ryo Yamamoto, Kimio Watanabe, Wan Jun Zhu, Ryoichi Nakazawa, Hiromi Hamada, Hodaka Suzuki, Masaaki Nakayama, Hiroyuki Terawaki, Noritomo Itami, Hirofumi Nakano, Naoyuki Osaka, Mariko Miyazaki |
| المصدر: | PLoS ONE PLoS ONE, Vol 12, Iss 9, p e0184535 (2017) |
| بيانات النشر: | Public Library of Science (PLoS), 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, Multivariate analysis, medicine.medical_treatment, Anti-Inflammatory Agents, 030232 urology & nephrology, lcsh:Medicine, Social Sciences, Cardiovascular Medicine, 030204 cardiovascular system & hematology, Pathology and Laboratory Medicine, Biochemistry, Mathematical and Statistical Techniques, 0302 clinical medicine, Medicine and Health Sciences, Psychology, lcsh:Science, Immune Response, Fatigue, Multidisciplinary, Confounding, Middle Aged, Nephrology, Cardiovascular Diseases, Physical Sciences, Sensory Perception, Female, Hemodialysis, Statistics (Mathematics), Research Article, medicine.medical_specialty, Immunology, Research and Analysis Methods, 03 medical and health sciences, Signs and Symptoms, Diagnostic Medicine, Renal Dialysis, Albumins, Internal medicine, Medical Dialysis, medicine, Humans, Hemoglobin, Statistical Methods, Serum Albumin, Antihypertensive Agents, Dialysis, Aged, Inflammation, business.industry, Pruritus, lcsh:R, Biology and Life Sciences, Proteins, Interim analysis, Clinical trial, Defined daily dose, Multivariate Analysis, Physical therapy, lcsh:Q, Observational study, business, Mathematics, Neuroscience, Hydrogen |
| الوصف: | Background and aim It is supposed that enhanced oxidative stress and inflammation are involved with the poor clinical outcomes in patients on chronic dialysis treatment. Recent studies have shown that molecular hydrogen (H2) is biologically active as an anti-inflammatory agent. Thus, we developed a novel hemodialysis (E-HD) system which delivers H2 (30 to 80 ppb)-enriched dialysis solution, to conduct a prospective observational study (UMIN000004857) in order to compare the long-term outcomes between E-HD and conventional-HD (C-HD) in Japan. The present interim analysis aimed to look at potential clinical effects of E-HD during the first 12 months observation. Subjects and method 262 patients (140, E-HD; 122, C-HD) were subjected for analysis for comprehensive clinical profiles. They were all participating in the above mentioned study, and they had been under the respective HD treatment for 12 consecutive months without hospitalization. Collected data, such as, physical and laboratory examinations, medications, and self-assessment questionnaires on subjective symptoms (i.e., fatigue and pruritus) were compared between the two groups. Results In a 12-month period, no clinical relevant differences were found in dialysis-related parameters between the two groups. However, there were differences in the defined daily dose of anti-hypertensive agents, and subjective symptoms, such as severe fatigue, and pruritus, which were all less in the E-HD group. Multivariate analysis revealed E-HD was an independent significant factor for the reduced use of anti-hypertensive agents as well as the absence of severe fatigue and pruritus at 12 months after adjusting for confounding factors. Conclusion The data indicates E-HD could have substantial clinical benefits beyond conventional HD therapy, and support the rationale to conduct clinical trials of H2 application to HD treatment. |
| تدمد: | 1932-6203 0000-0485 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ab1f88374f391fb1765c3ecf9d2227bTest https://doi.org/10.1371/journal.pone.0184535Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1ab1f88374f391fb1765c3ecf9d2227b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 00000485 |
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