miR-17-5p Regulates Endocytic Trafficking through Targeting TBC1D2/Armus
| العنوان: | miR-17-5p Regulates Endocytic Trafficking through Targeting TBC1D2/Armus |
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| المؤلفون: | Holger Erfle, Christoph Claas, Karl Rohr, Petr Matula, Nathalie Harder, Tautvydas Lisauskas, Lars Kaderali, Vania M.M. Braga, Vytaute Starkuviene, Andrius Serva, Roland Eils, Yueh-Tso Tsai, Bettina Knapp |
| المساهمون: | Medical Research Council (MRC), Cancer Research UK |
| المصدر: | PLoS ONE PLoS ONE, Vol 7, Iss 12, p e52555 (2012) |
| بيانات النشر: | Public Library of Science, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | GTPase-activating protein, Endocytic cycle, Gene Expression, GTPase, 0302 clinical medicine, Molecular cell biology, RNA interference, Basic Cancer Research, Regulation of gene expression, 0303 health sciences, Multidisciplinary, GTPase-Activating Proteins, Endocytosis, Transport protein, Cell biology, Nucleic acids, Gene Expression Regulation, Neoplastic, Protein Transport, Oncology, Science & Technology - Other Topics, Medicine, Membranes and Sorting, EPIDERMAL-GROWTH-FACTOR, Research Article, ENDOSOMAL TRAFFICKING, General Science & Technology, Science, Molecular Sequence Data, LOW-DENSITY-LIPOPROTEIN, Down-Regulation, Biology, Cell Growth, Molecular Genetics, 03 medical and health sciences, E-CADHERIN, MD Multidisciplinary, microRNA, Genetics, BREAST-CANCER, Humans, Gene Regulation, MESSENGER-RNAS, RNA, Messenger, 030304 developmental biology, Cell Proliferation, Science & Technology, Base Sequence, Epidermal Growth Factor, MULTIDISCIPLINARY SCIENCES, Gene Expression Profiling, CANCER CELL-PROLIFERATION, Reproducibility of Results, HAMSTER OVARY CELLS, MICRORNA CLUSTER, Protein Structure, Tertiary, Gene expression profiling, MicroRNAs, Receptors, LDL, RNA, 030217 neurology & neurosurgery, Function (biology), HeLa Cells |
| الوصف: | miRNA cluster miR-17-92 is known as oncomir-1 due to its potent oncogenic function. miR-17-92 is a polycistronic cluster that encodes 6 miRNAs, and can both facilitate and inhibit cell proliferation. Known targets of miRNAs encoded by this cluster are largely regulators of cell cycle progression and apoptosis. Here, we show that miRNAs encoded by this cluster and sharing the seed sequence of miR-17 exert their influence on one of the most essential cellular processes – endocytic trafficking. By mRNA expression analysis we identified that regulation of endocytic trafficking by miR-17 can potentially be achieved by targeting of a number of trafficking regulators. We have thoroughly validated TBC1D2/Armus, a GAP of Rab7 GTPase, as a novel target of miR-17. Our study reveals regulation of endocytic trafficking as a novel function of miR-17, which might act cooperatively with other functions of miR-17 and related miRNAs in health and disease. |
| وصف الملف: | (12) |
| اللغة: | English |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4d56ca70e8482c878ed15838ea54551Test http://europepmc.org/articles/PMC3527550Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b4d56ca70e8482c878ed15838ea54551 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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