Clinical relevance of plasma prostaglandin f2α metabolite concentrations in patients with idiopathic pulmonary fibrosis
| العنوان: | Clinical relevance of plasma prostaglandin f2α metabolite concentrations in patients with idiopathic pulmonary fibrosis |
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| المؤلفون: | Tomohiro Handa, Yoshio Taguchi, Kazuo Chin, Toru Oga, Kohei Ikezoe, Kiminobu Tanizawa, Michiaki Mishima, Kensaku Aihara, Athol U. Wells, Shuh Narumiya, Sonoko Nagai, Kizuku Watanabe, Hiroe Sato |
| المصدر: | PLoS ONE PLoS ONE, Vol 8, Iss 6, p e66017 (2013) |
| بيانات النشر: | Public Library of Science, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | medicine.medical_specialty, Vital capacity, Pulmonology, Epidemiology, Clinical Research Design, Metabolite, lcsh:Medicine, Interstitial Lung Diseases, Dinoprost, Gastroenterology, Pulmonary function testing, Immunoenzyme Techniques, chemistry.chemical_compound, Idiopathic pulmonary fibrosis, Diagnostic Medicine, Diffusing capacity, Internal medicine, Pulmonary fibrosis, Blood plasma, medicine, Pathology, Humans, lcsh:Science, Biology, Proportional Hazards Models, Multidisciplinary, medicine.diagnostic_test, Population Biology, business.industry, lcsh:R, medicine.disease, Echocardiography, Doppler, Idiopathic Pulmonary Fibrosis, Biomarker Epidemiology, Bronchoalveolar lavage, chemistry, Immunology, Observational Studies, Medicine, lcsh:Q, business, Biomarkers, Research Article, General Pathology |
| الوصف: | [Background]Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease of unknown etiology with few current treatment options. Recently, we determined an important role of prostaglandin F_{2α}(PGF_{2α}) in pulmonary fibrosis by using a bleomycin-induced pulmonary fibrosis model and found an abundance of PGF_{2α} in bronchoalveolar lavage fluid of IPF patients. We investigated the role of PGF_{2α} in human IPF by assessing plasma concentrations of 15-keto-dihydro PGF_{2α}, a stable metabolite of PGF_{2α}. [Methods]We measured plasma concentrations of 15-keto-dihydro PGF_{2α} in 91 IPF patients and compared these values with those of controls (n = 25). We further investigated the relationships of plasma 15-keto-dihydro PGF_{2α} concentrations with disease severity and mortality. [Results]Plasma concentrations of 15-keto-dihydro PGF_{2α} were significantly higher in IPF patients than controls (p |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb027ddb2c5568e1a8f94730f47667e5Test http://hdl.handle.net/2433/175816Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....eb027ddb2c5568e1a8f94730f47667e5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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