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StarD7 knockdown modulates ABCG2 expression, cell migration, proliferation, and differentiation of human choriocarcinoma JEG-3 cells

التفاصيل البيبلوغرافية
العنوان: StarD7 knockdown modulates ABCG2 expression, cell migration, proliferation, and differentiation of human choriocarcinoma JEG-3 cells
المؤلفون: Viviana Rena, Susana Genti-Raimondi, Sebastian Marquez, Jésica Flores-Martín, Graciela M. Panzetta-Dutari
المصدر: PLoS ONE
PLoS ONE, Vol 7, Iss 8, p e44152 (2012)
سنة النشر: 2012
مصطلحات موضوعية: Cellular differentiation, lcsh:Medicine, Pregnancy Proteins, Giant Cells, Biochemistry, Molecular cell biology, Endocrinology, Cell Movement, Gene expression, Morphogenesis, ATP Binding Cassette Transporter, Subfamily G, Member 2, Chorionic Gonadotropin, beta Subunit, Human, Choriocarcinoma, RNA, Small Interfering, lcsh:Science, Phospholipids, Gene knockdown, Multidisciplinary, Cell migration, Cell Differentiation, Transfection, Lipids, Cell biology, Neoplasm Proteins, Up-Regulation, Gene Expression Regulation, Neoplastic, Gene Knockdown Techniques, embryonic structures, Medicine, Research Article, STARD7, DNA transcription, Cell Migration, Biology, Cell Line, Tumor, Humans, Reproductive Endocrinology, Gene Silencing, RNA, Messenger, Cell Proliferation, Endocrine Physiology, Cell growth, lcsh:R, Gene Products, env, Proteins, Molecular biology, lcsh:Q, ATP-Binding Cassette Transporters, Carrier Proteins, Immunostaining, Biomarkers, Developmental Biology
الوصف: Background StAR-related lipid transfer domain containing 7 (StarD7) is a member of the START-domain protein family whose function still remains unclear. Our data from an explorative microarray assay performed with mRNAs from StarD7 siRNA-transfected JEG-3 cells indicated that ABCG2 (ATP-binding cassette sub-family G member 2) was one of the most abundantly downregulated mRNAs. Methodology/Principal Findings Here, we have confirmed that knocking down StarD7 mRNA lead to a decrease in the xenobiotic/lipid transporter ABCG2 at both the mRNA and protein levels (−26.4% and −41%, p
تدمد: 1932-6203
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d8630e8caa85e191e74cba6b0c372c3Test
https://pubmed.ncbi.nlm.nih.gov/22952907Test
حقوق: OPEN
رقم الانضمام: edsair.doi.dedup.....7d8630e8caa85e191e74cba6b0c372c3
قاعدة البيانات: OpenAIRE
الوصف
تدمد:19326203