التفاصيل البيبلوغرافية
| العنوان: |
I-FABP is decreased in COVID-19 patients, independently of the prognosis. |
| المؤلفون: |
Guedj, Kevin1 (AUTHOR) Kevin.guedj@gmail.com, Uzzan, Mathieu2 (AUTHOR), Soudan, Damien2 (AUTHOR), Trichet, Catherine3 (AUTHOR), Nicoletti, Antonino1 (AUTHOR), Weiss, Emmanuel4 (AUTHOR), Manceau, Hana5,6 (AUTHOR), Nuzzo, Alexandre2 (AUTHOR), Corcos, Olivier2 (AUTHOR), Treton, Xavier2,5 (AUTHOR), Peoc'h, Katell5,6 (AUTHOR) |
| المصدر: |
PLoS ONE. 4/15/2021, Vol. 16 Issue 4, p1-10. 10p. |
| مصطلحات موضوعية: |
*COVID-19, *LIPID metabolism, *FATTY acid-binding proteins, *SARS-CoV-2, *PROGNOSIS |
| مستخلص: |
Background: Severe acute respiratory syndrome caused by the novel coronavirus (SARS-CoV-2) is frequently associated with gastrointestinal manifestations. Herein we evaluated the interest in measuring the intestinal fatty acid-binding protein (I-FABP), a biomarker of intestinal injury, in COVID-19 patients. Methods: Serum I-FABP was analyzed in 28 consecutive patients hospitalized for a PCR-confirmed COVID-19, in 24 hospitalized patients with non-COVID-19 pulmonary diseases, and 79 patients admitted to the emergency room for abdominal pain. Results: I-FABP serum concentrations were significantly lower in patients with COVID-19, as compared to patients with non-COVID-19 pulmonary diseases [70.3 pg/mL (47–167.9) vs. 161.1 pg/mL (88.98–305.2), respectively, p = 0.008]. I-FABP concentrations in these two populations were significantly lower than in patients with abdominal pain without COVID-19 [344.8 pg/mL (268.9–579.6)]. I-FABP was neither associated with severity nor the duration of symptoms. I-FABP was correlated with polymorphonuclear cell counts. Conclusions: In this pilot study, we observed a low I-FABP concentration in COVID-19 patients either with or without gastrointestinal symptoms, of which the pathophysiological mechanisms and clinical impact remain to be established. Further explorations on a larger cohort of patients will be needed to unravel the molecular mechanism of such observation, including the effects of malabsorption and/or abnormal lipid metabolism. [ABSTRACT FROM AUTHOR] |
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