SIL-TAL1 Rearrangement is Related with Poor Outcome: A Study from a Chinese Institution
| العنوان: | SIL-TAL1 Rearrangement is Related with Poor Outcome: A Study from a Chinese Institution |
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| المؤلفون: | Shiqiu Zhou, Jing He, Xiaoxi Zhou, Jianfeng Zhou, Danmei Xu, Liang Huang, Lijun Jiang, Na Wang, Jie Xiong, Yunfan Yang, Guangrong Zhu, Chunrui Li, Di Wang |
| المصدر: | PLoS ONE PLoS ONE, Vol 8, Iss 9, p e73865 (2013) |
| بيانات النشر: | Public Library of Science (PLoS), 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Adolescent, Oncogene Proteins, Fusion, medicine.medical_treatment, lcsh:Medicine, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Gastroenterology, Translocation, Genetic, Mice, Young Adult, Immunophenotyping, hemic and lymphatic diseases, Internal medicine, White blood cell, medicine, Animals, Humans, Young adult, lcsh:Science, Child, Retrospective Studies, Disseminated intravascular coagulation, Chemotherapy, Multidisciplinary, business.industry, lcsh:R, Retrospective cohort study, Disseminated Intravascular Coagulation, Middle Aged, Prognosis, medicine.disease, Xenograft Model Antitumor Assays, Patient Outcome Assessment, Tumor lysis syndrome, Disease Models, Animal, Leukemia, Phenotype, medicine.anatomical_structure, Child, Preschool, Immunology, RNA-Binding Protein FUS, lcsh:Q, Female, Tumor Lysis Syndrome, business, Research Article |
| الوصف: | SIL-TAL1 rearrangement is common in T-cell acute lymphoblastic leukemia (T-ALL), however its prognostic implication remains controversial. To investigate the clinical characteristics and outcome of this subtype in Chinese population, we systemically reviewed 62 patients with newly diagnosed T-ALL, including 15 patients with SIL-TAL1 rearrangement. We found that SIL-TAL1(+) T-ALL was characterized by higher white blood cell count (P = 0.029) at diagnosis, predominant cortical T-ALL immunophenotype (P = 0.028) of the leukemic blasts, and a higher prevalence of tumor lysis syndrome (TLS, P |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::381c8131fa6ddb3808d70e96e5c6d7a6Test https://doi.org/10.1371/journal.pone.0073865Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....381c8131fa6ddb3808d70e96e5c6d7a6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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