Use of Morphometric Mapping to Characterise Symptomatic Chiari-Like Malformation, Secondary Syringomyelia and Associated Brachycephaly in the Cavalier King Charles Spaniel
| العنوان: | Use of Morphometric Mapping to Characterise Symptomatic Chiari-Like Malformation, Secondary Syringomyelia and Associated Brachycephaly in the Cavalier King Charles Spaniel |
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| المؤلفون: | Susan P. Knowler, Sandra Griffiths, Clare Rusbridge, Roberto M. La Ragione, Angus McFadyen, Jelena Jovanovik, Colin J. Driver, Zoha Kibar, Chloe Cross, Anna Tauro |
| المصدر: | PLoS ONE PLoS ONE, Vol 12, Iss 1, p e0170315 (2017) |
| بيانات النشر: | Public Library of Science, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Physiology, lcsh:Medicine, Breeding, Nervous System, Diagnostic Radiology, 0403 veterinary science, Medicine and Health Sciences, Medicine, Dog Diseases, Foramen Magnum, lcsh:Science, Musculoskeletal System, Cerebrospinal Fluid, Mammals, Observer Variation, Skull Base, Multidisciplinary, medicine.diagnostic_test, biology, Radiology and Imaging, Brain, Discriminant Analysis, 04 agricultural and veterinary sciences, Anatomy, Magnetic Resonance Imaging, Olfactory Bulb, Body Fluids, Arnold-Chiari Malformation, medicine.anatomical_structure, Phenotype, Spinal Cord, Vertebrates, Cervical Vertebrae, Female, Brachycephaly, Syringomyelia, Research Article, Fossa, 040301 veterinary sciences, Imaging Techniques, Cephalometry, Research and Analysis Methods, 03 medical and health sciences, Craniosynostoses, Dogs, Diagnostic Medicine, Animals, Genetic Predisposition to Disease, Skeleton, Retrospective Studies, business.industry, Morphometry, lcsh:R, Skull, Organisms, Biology and Life Sciences, Reproducibility of Results, Magnetic resonance imaging, Spinal cord, medicine.disease, biology.organism_classification, Hindbrain, Rhombencephalon, Neuroanatomy, 030104 developmental biology, Forebrain, Amniotes, lcsh:Q, Olfactory Lobe, business, Neuroscience |
| الوصف: | Objectives To characterise the symptomatic phenotype of Chiari-like malformation (CM), secondary syringomyelia (SM) and brachycephaly in the Cavalier King Charles Spaniel using morphometric measurements on mid-sagittal Magnetic Resonance images (MRI) of the brain and craniocervical junction. Methods This retrospective study, based on a previous quantitative analysis in the Griffon Bruxellois (GB), used 24 measurements taken on 130 T1-weighted MRI of hindbrain and cervical region. Associated brachycephaly was estimated using 26 measurements, including rostral forebrain flattening and olfactory lobe rotation, on 72 T2-weighted MRI of the whole brain. Both study cohorts were divided into three groups; Control, CM pain and SM and their morphometries compared with each other. Results Fourteen significant traits were identified in the hindbrain study and nine traits in the whole brain study, six of which were similar to the GB and suggest a common aetiology. The Control cohort had the most elliptical brain (p = 0.010), least olfactory bulb rotation (p = 0.003) and a protective angle (p = 0.004) compared to the other groups. The CM pain cohort had the greatest rostral forebrain flattening (p = 0.007), shortest basioccipital (p = 0.019), but a greater distance between the atlas and basioccipital (p = 0.002) which was protective for SM. The SM cohort had two conformation anomalies depending on the severity of craniocervical junction incongruities; i) the proximity of the dens (p |
| وصف الملف: | text |
| اللغة: | English |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c754fdfcc9b8479da5992b20077129f8Test http://europepmc.org/articles/PMC5266281Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c754fdfcc9b8479da5992b20077129f8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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