Diabetes mellitus in patients with chronic obstructive pulmonary disease-The impact on mortality
| العنوان: | Diabetes mellitus in patients with chronic obstructive pulmonary disease-The impact on mortality |
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| المؤلفون: | Chun-Ta Huang, Chong-Jen Yu, Feipei Lai, Sheng-Yuan Ruan, Te-Wei Ho, Yi-Ju Tsai |
| المصدر: | PLoS ONE PLoS ONE, Vol 12, Iss 4, p e0175794 (2017) |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, Critical Care and Emergency Medicine, Databases, Factual, National Health Programs, Pulmonology, lcsh:Medicine, Blood Pressure, Comorbidity, Kaplan-Meier Estimate, 030204 cardiovascular system & hematology, Vascular Medicine, Coronary artery disease, Cohort Studies, Pulmonary Disease, Chronic Obstructive, 0302 clinical medicine, Endocrinology, Risk Factors, Medicine and Health Sciences, Coronary Heart Disease, lcsh:Science, COPD, education.field_of_study, Multidisciplinary, Incidence, Hazard ratio, Middle Aged, Prognosis, Neurology, Hypertension, Female, Cohort study, Research Article, Adult, medicine.medical_specialty, Endocrine Disorders, Chronic Obstructive Pulmonary Disease, Cerebrovascular Diseases, Population, Taiwan, Cardiology, 03 medical and health sciences, Internal medicine, Diabetes mellitus, medicine, Diabetes Mellitus, Humans, education, Propensity Score, Aged, Proportional Hazards Models, Heart Failure, Proportional hazards model, business.industry, lcsh:R, medicine.disease, Diabetes Mellitus, Type 1, 030228 respiratory system, Dyslipidemia, Metabolic Disorders, lcsh:Q, business, Follow-Up Studies |
| الوصف: | Background Chronic obstructive pulmonary disease (COPD) is the leading cause of morbidity and mortality worldwide. There is evidence to support a connection between COPD and diabetes mellitus (DM), another common medical disorder. However, additional research is required to improve our knowledge of these relationships and their possible implications. In this study, we investigated the impact of DM on patient outcomes through the clinical course of COPD. Methods We conducted a cohort study in patients from the Taiwan Longitudinal Health Insurance Database between 2000 and 2013. Patients with COPD were identified and assessed for pre-existing and incident DM. A Cox proportional hazards model was built to identify factors associated with incident DM and to explore the prognostic effects of DM on COPD patients. A propensity score method was used to match COPD patients with incident DM to controls without incident DM. Results Pre-existing DM was present in 332 (16%) of 2015 COPD patients who had a significantly higher hazard ratio (HR) [1.244, 95% confidence interval (CI) 1.010–1.532] for mortality than that of the COPD patients without pre-existing DM. During the 10-year follow-up period, 304 (19%) of 1568 COPD patients developed incident DM; comorbid hypertension (HR, 1.810; 95% CI, 1.363–2.403), cerebrovascular disease (HR, 1.517; 95% CI, 1.146–2.008) and coronary artery disease (HR, 1.408; 95% CI 1.089–1.820) were significant factors associated with incident DM. Survival was worse for the COPD patients with incident DM than for the matched controls without incident DM (Log-rank, p = 0.027). Conclusions DM, either pre-existing or incident, was associated with worse outcomes in COPD patients. Targeted surveillance and management of DM may be important in clinical care of the COPD population. |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1063e976b02bedb1a860322a19f42026Test https://pubmed.ncbi.nlm.nih.gov/28410410Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1063e976b02bedb1a860322a19f42026 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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