Yessotoxin, a Marine Toxin, Exhibits Anti-Allergic and Anti-Tumoural Activities Inhibiting Melanoma Tumour Growth in a Preclinical Model
| العنوان: | Yessotoxin, a Marine Toxin, Exhibits Anti-Allergic and Anti-Tumoural Activities Inhibiting Melanoma Tumour Growth in a Preclinical Model |
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| المؤلفون: | Luis M. Botana, Iris K. Madera-Salcedo, Ulrich Blank, Amparo Alfonso, Araceli Tobío |
| المساهمون: | Universidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica |
| المصدر: | PLoS ONE, Vol 11, Iss 12, p e0167572 (2016) PLoS ONE Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela instname |
| بيانات النشر: | Public Library of Science (PLoS), 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Melanomas, 0301 basic medicine, Cancer Treatment, lcsh:Medicine, Apoptosis, Toxicology, Pathology and Laboratory Medicine, Mice, chemistry.chemical_compound, 0302 clinical medicine, Anti-Allergic Agents, Medicine and Health Sciences, Toxins, lcsh:Science, Cytotoxicity, Cultured Tumor Cells, Staining, Multidisciplinary, Cell Death, Chemistry, Oxocins, Cell Staining, Animal Models, Mast cell, 3. Good health, medicine.anatomical_structure, Oncology, Cell Processes, 030220 oncology & carcinogenesis, Dinoflagellida, Melanoma Cells, Biological Cultures, Yessotoxin, Research Article, Cell Survival, Toxic Agents, Mollusk Venoms, Mouse Models, Antineoplastic Agents, Research and Analysis Methods, Microbiology, 03 medical and health sciences, Model Organisms, In vivo, Cell Line, Tumor, medicine, Animals, Humans, Cell Proliferation, Toxicity, Cell growth, lcsh:R, Biology and Life Sciences, Cancers and Neoplasms, Cell Biology, Cell Cultures, 030104 developmental biology, Specimen Preparation and Treatment, Cell culture, Cancer research, Marine Toxins, lcsh:Q, Marine toxin |
| الوصف: | Yessotoxins (YTXs) are a group of marine toxins produced by the dinoflagellates Protoceratium reticulatum, Lingulodinium polyedrum and Gonyaulax spinifera. They may have medical interest due to their potential role as anti-allergic but also anti-cancer compounds. However, their biological activities remain poorly characterized. Here, we show that the small molecular compound YTX causes a slight but significant reduction of the ability of mast cells to degranulate. Strikingly, further examination revealed that YTX had a marked and selective cytotoxicity for the RBL-2H3 mast cell line inducing apoptosis, while primary bone marrow derived mast cells were highly resistant. In addition, YTX exhibited strong cytotoxicity against the human B-chronic lymphocytic leukaemia cell line MEC1 and the murine melanoma cell line B16F10. To analyse the potential role of YTX as an anti-cancer drug in vivo we used the well-established B16F10 melanoma preclinical mouse model. Our results demonstrate that a few local application of YTX around established tumours dramatically diminished tumour growth in the absence of any significant toxicity as determined by the absence of weight loss and haematological alterations. Our data support that YTX may have a minor role as an anti-allergic drug, but reveals an important potential for its use as an anti-cancer drug Dr. Araceli Tobio Ageitos was supported by a postdoctoral fellowship from Fundación Juana de Vega, Spain. Dr. Iris Madera-Salcedo was supported by an International collaboration grant between ANR France (ANR-12-ISV3-0006-01) and Conacyt Mexico (Conacyt-ANR 188565). This research project has been supported by the Investissements d’Avenir programme ANR-11-IDEX-0005-02, Sorbonne Paris Cite, Laboratoire d’excellence INFLAMEX, and DHU Fire. This work was also supported by the COST Action BM1007 (Mast cells and basophils–targets for innovative therapies) of the European Community SI |
| وصف الملف: | application/pdf |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef08f5dd082562bfe9cd2b1decf9185fTest https://doi.org/10.1371/journal.pone.0167572Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ef08f5dd082562bfe9cd2b1decf9185f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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