Frequent Transient Hepatitis C viremia without Seroconversion among Healthcare Workers in Cairo, Egypt
| العنوان: | Frequent Transient Hepatitis C viremia without Seroconversion among Healthcare Workers in Cairo, Egypt |
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| المؤلفون: | Mohamed Momen, Diaa Marzouk, Jacques Izopet, Matthew L. Albert, Hanan Said Ezz elarab, Mostafa El-Hosini, Aline Munier, Elisabeth Delarocque-Astagneau, Omar Okasha, Lénaig Le Fouler, Mona Rafik, Mai El-Daly, Mostafa K. Mohamed, Rasha Mamdouh, Sylvia Taylor, Mohamed Abdel-Hamid, Dalia G. Sos, Florence Abravanel, Arnaud Fontanet, Waleed Salah Eldin |
| المساهمون: | Epidémiologie des Maladies Emergentes - Emerging Diseases Epidemiology, Pasteur-Cnam Risques infectieux et émergents (PACRI), Institut Pasteur [Paris]-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Institut Pasteur [Paris]-Conservatoire National des Arts et Métiers [CNAM] (CNAM), Université Ain Shams, Centre de Physiopathologie Toulouse Purpan (CPTP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), National Hepatology & Tropical Medicine Research Institute, Menoufia University, National Liver Institute [Menoufia, Egypt], Menoufia University [Egypte]-Menoufia University [Egypte], Faculty of medicine, Immunobiologie des Cellules Dendritiques, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Minia University, This work was supported by the Agence nationale de recherches sur le Sida et les Hépatites virales,France, grant number ANRS 12171, We gratefully thank the healthcare workers who accepted to be part of the study. We are grateful to Dina Aly and Ghada Wassef, Faculty of Medicine, Ain Shams University, Cairo, for their help in monitoring follow-up of HCWs, to Melissa Laird, Institut Pasteur/INSERM, for her collaboration in the immunology team, to all participating prick injury clinics, to Prof. Ghada Ismail, Head of Central Unit for Infection Control in Ain Shams and her staff, to Prof. Wagida Anwar, Head of Department of Community, Environmental and Occupational Medicine at the Faculty of Medicine, Ain Shams University, Cairo, and to Prof. Ahmed Nassar, Dean of Ain Shams University Hospital, for allowing the conduct of the study in Ain Shams University hospitals., Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Vougny, Marie-Christine |
| المصدر: | PLoS ONE PLoS ONE, Public Library of Science, 2013, 8 (2), pp.e57835. ⟨10.1371/journal.pone.0057835⟩ PLoS ONE, 2013, 8 (2), pp.e57835. ⟨10.1371/journal.pone.0057835⟩ PLoS ONE, Vol 8, Iss 2, p e57835 (2013) |
| بيانات النشر: | Public Library of Science, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Male, Non-Clinical Medicine, Epidemiology, Gastroenterology and hepatology, Health Care Providers, MESH: Occupational Exposure/statistics & numerical data, MESH: Viremia/epidemiology, MESH: Egypt/epidemiology, medicine.disease_cause, MESH: Hepatitis C/transmission, Hepatitis, Cohort Studies, 0302 clinical medicine, Health care, Medicine, 030212 general & internal medicine, Prospective Studies, Young adult, 0303 health sciences, education.field_of_study, Multidisciplinary, virus diseases, Hepatitis C, 3. Good health, Infectious hepatitis, MESH: Young Adult, MESH: Hepatitis C/blood, [SDV.IMM]Life Sciences [q-bio]/Immunology, Infectious diseases, Egypt, Female, Public Health, Viral load, Research Article, Adult, [SDV.IMM] Life Sciences [q-bio]/Immunology, Clinical Research Design, Science, Hepatitis C virus, Health Personnel, Population, Viremia, Viral diseases, MESH: Viremia/transmission, MESH: Hepatitis C/epidemiology, Infectious Disease Epidemiology, 03 medical and health sciences, Young Adult, Environmental health, Occupational Exposure, Humans, Seroconversion, MESH: Health Personnel/statistics & numerical data, education, Liver diseases, 030304 developmental biology, MESH: Humans, business.industry, MESH: Adult, medicine.disease, Virology, MESH: Male, digestive system diseases, MESH: Viremia/blood, business, MESH: Female |
| الوصف: | BackgroundsWith 10% of the general population aged 15-59 years chronically infected with hepatitis C virus (HCV), Egypt is the country with the highest HCV prevalence worldwide. Healthcare workers (HCWs) are therefore at particularly high risk of HCV infection. Our aim was to study HCV infection risk after occupational blood exposure among HCWs in Cairo.Methodology/principal findingsThe study was conducted in 2008-2010 at Ain Shams University Hospital, Cairo. HCWs reporting an occupational blood exposure at screening, having neither anti-HCV antibodies (anti-HCV) nor HCV RNA, and exposed to a HCV RNA positive patient, were enrolled in a 6-month prospective cohort with follow-up visits at weeks 2, 4, 8, 12 and 24. During follow-up, anti-HCV, HCV RNA and ALT were tested. Among 597 HCWs who reported a blood exposure, anti-HCV prevalence at screening was 7.2%, not different from that of the general population of Cairo after age-standardization (11.6% and 10.4% respectively, p = 0.62). The proportion of HCV viremia among index patients was 37%. Of 73 HCWs exposed to HCV RNA from index patients, nine (12.3%; 95%CI, 5.8-22.1%) presented transient viremia, the majority of which occurred within the first two weeks after exposure. None of the workers presented seroconversion or elevation of ALT.Conclusions/significanceHCWs of a general University hospital in Cairo were exposed to a highly viremic patient population. They experienced frequent occupational blood exposures, particularly in early stages of training. These exposures resulted in transient viremic episodes without established infection. These findings call for further investigation of potential immune protection against HCV persistence in this high risk group. |
| وصف الملف: | application/force-download |
| اللغة: | English |
| تدمد: | 1932-6203 2008-2010 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89d3e9cdb2f1e6cf3d20768a840952dcTest http://europepmc.org/articles/PMC3585182Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....89d3e9cdb2f1e6cf3d20768a840952dc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 20082010 |
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