دورية أكاديمية
The dual orexin/hypocretin receptor antagonist, almorexant, in the ventral tegmental area attenuates ethanol self-administration
| العنوان: | The dual orexin/hypocretin receptor antagonist, almorexant, in the ventral tegmental area attenuates ethanol self-administration |
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| المؤلفون: | Srinivasan, Subhashini, Simms, Jeffrey, Nielsen, Carsten, Lieske, Steven, Bito-Onon, Jade, Yi, Henry, Hopf, F. Woodward, Bonci, Antonello, Bartlett, Selena |
| المصدر: | PLoS One |
| بيانات النشر: | Public Library of Science |
| سنة النشر: | 2012 |
| المجموعة: | Queensland University of Technology: QUT ePrints |
| مصطلحات موضوعية: | addiction, alcohol, electrophysiology, orexin or hypocretin, ventral tegmental area |
| الوصف: | Recent studies have implicated the hypocretin/orexinergic system in reward-seeking behavior. Almorexant, a dual orexin/hypocretin R1 and R2 receptor antagonist, has proven effective in preclinical studies in promoting sleep in animal models and was in Phase III clinical trials for sleep disorders. The present study combines behavioral assays with in vitro biochemical and electrophysiological techniques to elucidate the role of almorexant in ethanol and sucrose intake. Using an operant self-administration paradigm, we demonstrate that systemic administration of almorexant decreased operant selfadministration of both 20% ethanol and 5% sucrose. We further demonstrate that intraventral tegmental area (VTA) infusions, but not intra substantia nigra infusions, of almorexant reduced ethanol self-administration. Extracellular recordings performed in VTA neurons revealed that orexin-A increased firing and this enhancement of firing was blocked by almorexant. The results demonstrate that orexin/hypocretin receptors in distinct brain regions regulate ethanol and sucrose mediated behaviors. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| العلاقة: | https://eprints.qut.edu.au/53740/10/journal.pone.0044726.pdfTest; Srinivasan, Subhashini, Simms, Jeffrey, Nielsen, Carsten, Lieske, Steven, Bito-Onon, Jade, Yi, Henry, Hopf, F. Woodward, Bonci, Antonello, & Bartlett, Selena (2012) The dual orexin/hypocretin receptor antagonist, almorexant, in the ventral tegmental area attenuates ethanol self-administration. PLoS One, 7(9), pp. 1-12.; https://eprints.qut.edu.au/53740Test/; Faculty of Health; Institute of Health and Biomedical Innovation; School of Clinical Sciences |
| الإتاحة: | https://doi.org/10.1371/journal.pone.0044726Test https://eprints.qut.edu.au/53740Test/ |
| حقوق: | free_to_read ; http://creativecommons.org/licenses/by/2.5Test/ ; Consult author(s) regarding copyright matters ; This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au |
| رقم الانضمام: | edsbas.FCF30B54 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |