التفاصيل البيبلوغرافية
| العنوان: |
A high-fat and fructose diet in dogs mirrors insulin resistance and β-cell dysfunction characteristic of impaired glucose tolerance in humans. |
| المؤلفون: |
Gregory, Justin M., Kraft, Guillaume, Dalla Man, Chiara, Slaughter, James C., Scott, Melanie F., Hastings, Jon R., Edgerton, Dale S., Moore, Mary C., Cherrington, Alan D. |
| المصدر: |
PLoS ONE; 12/22/2023, Vol. 18 Issue 12, p1-16, 16p |
| مصطلحات موضوعية: |
HIGH-fat diet, INSULIN resistance, DOGS, INSULIN, TYPE 2 diabetes, FRUCTOSE, GLUCOSE tolerance tests, INSULIN sensitivity |
| مستخلص: |
This study examined the impact of a hypercaloric high-fat high-fructose diet (HFFD) in dogs as a potential model for human impaired glucose tolerance (IGT) and type 2 diabetes mellitus (T2DM). The HFFD not only led to weight gain but also triggered metabolic alterations akin to the precursors of human T2DM, notably insulin resistance and β-cell dysfunction. Following the HFFD intervention, the dogs exhibited a 50% decrease in insulin sensitivity within the first four weeks, paralleling observations in the progression from normal to IGT in humans. Calculations of the insulinogenic index using both insulin and C-peptide measurements during oral glucose tolerance tests revealed a significant and sustained decrease in early-phase insulin release, with partial compensation in the later phase, predominantly stemming from reduced hepatic insulin clearance. In addition, the Disposition Index, representing the β-cell's capacity to compensate for diminished insulin sensitivity, fell dramatically. These results confirm that a HFFD can instigate metabolic changes in dogs akin to the early stages of progression to T2DM in humans. The study underscores the potential of using dogs subjected to a HFFD as a model organism for studying human IGT and T2DM. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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