دورية أكاديمية
Increased platelet content of SDF-1alpha is associated with worse prognosis in patients with pulmonary prterial hypertension
| العنوان: | Increased platelet content of SDF-1alpha is associated with worse prognosis in patients with pulmonary prterial hypertension |
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| المؤلفون: | Remigiusz Kazimierczyk, Piotr Blaszczak, Małgorzata Jasiewicz, Małgorzata Knapp, Katarzyna Ptaszynska-Kopczynska, Bozena Sobkowicz, Ewa Waszkiewicz, Ryszard Grzywna, Wlodzimierz J. Musial, Karol A. Kaminski |
| المصدر: | Platelets, Vol 30, Iss 4, Pp 445-451 (2019) |
| بيانات النشر: | Taylor & Francis Group, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Diseases of the blood and blood-forming organs |
| مصطلحات موضوعية: | interleukin 6, interleukin 6 receptor, platelets, pulmonary arterial hypertension, sdf-1, Diseases of the blood and blood-forming organs, RC633-647.5 |
| الوصف: | Inflammatory processes and platelet activity play an important role in the pathophysiology of pulmonary arterial hypertension (PAH). Enhanced IL-6 signaling and higher concentration of stromal-derived factor alpha (SDF-1) have been previously shown to be linked with prognosis in PAH. We hypothesized that platelets of PAH patients have higher content of IL-6 and SDF-1 and thus are involved in disease progression. We enrolled into study 22 PAH patients and 18 healthy controls. Patients with PAH presented significantly higher plasma concentrations and platelet contents of IL-6, sIL-6R, and SDF-1 than healthy subjects (platelet content normalized to protein concentration: IL-6 (0.85*10–10 [0.29 – 1.37] vs. 0.45*10–10 [0.19–0.65], sIL-6R 1.54*10–7 [1.32–2.21] vs. 1.14*10–7 [1.01–1.28] and SDF-1 (2.72*10–7 [1.85–3.23] vs. 1.70*10–7 [1.43–2.60], all p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0953-7104 1369-1635 09537104 |
| العلاقة: | https://doaj.org/toc/0953-7104Test; https://doaj.org/toc/1369-1635Test |
| DOI: | 10.1080/09537104.2018.1457780 |
| الوصول الحر: | https://doaj.org/article/d651738f0d6449ffa12b63a156920268Test |
| رقم الانضمام: | edsdoj.651738f0d6449ffa12b63a156920268 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 09537104 13691635 |
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| DOI: | 10.1080/09537104.2018.1457780 |