Evaluation of the Antidiabetic and Antihyperlipidemic Activity of Spondias purpurea Seeds in a Diabetic Zebrafish Model
| العنوان: | Evaluation of the Antidiabetic and Antihyperlipidemic Activity of Spondias purpurea Seeds in a Diabetic Zebrafish Model |
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| المؤلفون: | Abraham Heriberto Garcia-Campoy, Alethia Muñiz-Ramirez, Rosa Martha Perez Gutierrez, Jose Maria Mota Flores, Efren Garcia Baez |
| المصدر: | Plants, Vol 10, Iss 1417, p 1417 (2021) Plants Volume 10 Issue 7 |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Heart disease, antiglycation activity, medicine.medical_treatment, Plant Science, Disease, Pharmacology, Spondias purpurea, Article, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Glycation, Diabetes mellitus, medicine, Ecology, Evolution, Behavior and Systematics, Ecology, diabetes, business.industry, Cholesterol, Insulin, Botany, medicine.disease, zebrafish, 030104 developmental biology, chemistry, QK1-989, business, 030217 neurology & neurosurgery, Retinopathy, Kidney disease |
| الوصف: | Diabetes mellitus (DM) is a serious chronic degenerative disease characterized by high levels of glucose in the blood. It is associated with an absolute or relative deficiency in the production and/or action of insulin. Some of the complications associated with DM are heart disease, retinopathy, kidney disease, and neuropathy therefore, new natural alternatives are being sought to control the disease. In this work, we evaluate the antidiabetic effect of Spondias purpurea seed methanol extract (CSM) in vitro and in a glucose-induced diabetic zebrafish model. CSM is capable of lowering blood glucose and cholesterol levels, as well as forming advanced glycation end-products, while not presenting toxic effects at the concentrations evaluated. These data show that CSM has a promising antidiabetic effect and may be useful in reducing some of the pathologies associated with diabetes mellitus. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2223-7747 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ff376f647c52249634faeaac8b033b8Test https://www.mdpi.com/2223-7747/10/7/1417Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3ff376f647c52249634faeaac8b033b8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22237747 |
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