التفاصيل البيبلوغرافية
| العنوان: |
Metformin monotherapy in melanoma: a pilot, open-label, prospective, and multicentric study indicates no benefit. |
| المؤلفون: |
Montaudié, Henri, Cerezo, Michael, Bahadoran, Philippe, Roger, Coralie, Passeron, Thierry, Machet, Laurent, Arnault, Jean ‐ Philippe, Verneuil, Laurence, Maubec, Eve, Aubin, François, Granel, Florence, Giacchero, Damien, Hofman, Véronique, Lacour, Jean ‐ Philippe, Maryline, Allegra, Ballotti, Robert, Rocchi, Stéphane |
| المصدر: |
Pigment Cell & Melanoma Research; May2017, Vol. 30 Issue 3, p378-380, 3p |
| مصطلحات موضوعية: |
METFORMIN, MELANOMA treatment, TREATMENT effectiveness, BRAF genes, BIGUANIDE, GENETIC mutation |
| مستخلص: |
The article discusses a study conducted to evaluate the effectiveness of metformin monotherapy in treating melanoma. Metformin was found to have no significant efficacy in mouse models and that its combination with BRAF inhibitor or MEK inhibitor may achieve potential therapeutic advantage. The use of BRAFi in combination with biguanide was also noted to have stronger antiproliferative effects on mutant cell lines. |
| قاعدة البيانات: |
Complementary Index |
