التفاصيل البيبلوغرافية
| العنوان: |
Effects of Microdesmis keayana alkaloids on vascular parameters of erectile dysfunction. |
| المؤلفون: |
Zamblé, Alexis, Martin-Nizard, Françoise, Sahpaz, Sevser, Reynaert, Marie-Line, Staels, Bart, Bordet, Régis, Duriez, Patrick, Gressier, Bernard, Bailleul, François |
| المصدر: |
Phytotherapy Research; Jun2009, Vol. 23 Issue 6, p892-895, 4p |
| مستخلص: |
Microdesmis keayana (Pandaceae) is an African tropical plant whose roots are used in traditional medicine for erection impairment but the compounds responsible for its action are unknown. Two major alkaloids recently isolated from the roots of M. keayana, keayanidine B and keayanine, were tested for vasorelaxing properties using isolated rat aortic rings precontracted by phenylephrine to confirm its traditional use. Influence of the alkaloids on the endothelial production of endothelial nitric oxide synthase (eNOS) was measured by quantitative polymerase chain reaction (QPCR) analysis. Scavenging activities were assessed versus 1,1-diphenyl-2-picrylhydrazyle (DPPH) and reactive oxygen species (ROS) such as superoxide anion (O [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
