التفاصيل البيبلوغرافية
| العنوان: |
Novel insights into the biomolecular mechanism of action of 4′-geranyloxyferulic acid, a colon cancer chemopreventive agent. |
| المؤلفون: |
Palumbo, Lucia1 (AUTHOR), Genovese, Salvatore1 (AUTHOR) s.genovese@unich.it, Collevecchio, Chiara1 (AUTHOR), Epifano, Francesco1 (AUTHOR) francesco.epifano@unich.it, Fiorito, Serena1 (AUTHOR) serena.fiorito@unich.it |
| المصدر: |
Phytochemistry. Jul2023, Vol. 211, pN.PAG-N.PAG. 1p. |
| مصطلحات موضوعية: |
*COLON cancer, *CYTOCHROME c, *REACTIVE oxygen species, *CASPASES, *CELL survival |
| مستخلص: |
In this manuscript the biomolecular mechanism of action of the natural colon cancer chemopreventive agent 4′-geranyloxyferulic acid in cultured Caco-2 cells has been investigated. It was first demonstrated how the application of this phytochemical led to a time- and dose-dependent decrease of cell viability and in parallel to a massive generation of reactive oxygen species and induction of caspases 3 and 9, finally providing apoptosis. This event is accompanied by deep modifications in key pro-apoptotic targets like CD95, DR4 and 5, cytochrome c , Apaf-1, Bcl-2, and Bax. Such effects can explain the large apoptosis recorded in Caco-2 cells treated with 4′-geranyloxyferulic acid. 4′-Geranyloxyferulic acid deeply interfere with mitochondrial functions in cultured Caco-2 cells leading to apoptosis. CD95, DR4 and 5, cytochrome c , Apaf-1, Bcl-2, and Bax have been found as the main targets of this secondary metabolite. [Display omitted] • The effects of 4′-geranyloxyferulic acid in Caco-2 cells were investigated. • A time- and dose-dependent decrease of cell viability was recorded. • A massive generation of ROS and induction of caspases 3 and 9 occurred. • CD95, DR4 and 5, cytochrome c , Apaf-1, Bcl-2, and Bax were triggered. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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