Reward Processing by the Opioid System in the Brain
| العنوان: | Reward Processing by the Opioid System in the Brain |
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| المؤلفون: | Jérôme A.J. Becker, Brigitte L. Kieffer, Katia Befort, Julie Le Merrer |
| المساهمون: | Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique, Institut de la Santé et de la Recherche Médicale, and Université de Strasbourg, Agence Nationale pour la Recherche, European Union (GENADDICT/FP6 005166), National Institutes of Health (NIAAA AA-16658, NIDA DA-16768, NIDA DA-05010), Peney, Maité, Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA) |
| المصدر: | Physiological Reviews Physiological Reviews, 2009, 89 (4), pp.1379-412. ⟨10.1152/physrev.00005.2009⟩ Physiological Reviews, American Physiological Society, 2009, 89 (4), pp.1379-412. ⟨10.1152/physrev.00005.2009⟩ Physiological Reviews 4 (89), 1379-1412. (2009) |
| بيانات النشر: | American Physiological Society, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Médicaments, Drug, [SDV.SP.MED] Life Sciences [q-bio]/Pharmaceutical sciences/Medication, Substance-Related Disorders, Physiology, media_common.quotation_subject, drogue, Dynorphin, Medication, Article, 03 medical and health sciences, 0302 clinical medicine, Reward, [SDV.SP.MED]Life Sciences [q-bio]/Pharmaceutical sciences/Medication, système opioïde, Physiology (medical), animal modèle, medicine, Animals, Humans, RNA, Messenger, Opioid peptide, Receptor, Molecular Biology, 030304 developmental biology, media_common, Endogenous opioid, 0303 health sciences, Addiction, Brain, General Medicine, 3. Good health, Proenkephalin, Opioid, Receptors, Opioid, cerveau, Endorphins, Psychology, récepteur, Reinforcement, Psychology, Neuroscience, 030217 neurology & neurosurgery, medicine.drug |
| الوصف: | International audience; The opioid system consists of three receptors, mu, delta, and kappa, which are activated by endogenous opioid peptides processed from three protein precursors, proopiomelanocortin, proenkephalin, and prodynorphin. Opioid receptors are recruited in response to natural rewarding stimuli and drugs of abuse, and both endogenous opioids and their receptors are modified as addiction develops. Mechanisms whereby aberrant activation and modifications of the opioid system contribute to drug craving and relapse remain to be clarified. This review summarizes our present knowledge on brain sites where the endogenous opioid system controls hedonic responses and is modified in response to drugs of abuse in the rodent brain. We review 1) the latest data on the anatomy of the opioid system, 2) the consequences of local intracerebral pharmacological manipulation of the opioid system on reinforced behaviors, 3) the consequences of gene knockout on reinforced behaviors and drug dependence, and 4) the consequences of chronic exposure to drugs of abuse on expression levels of opioid system genes. Future studies will establish key molecular actors of the system and neural sites where opioid peptides and receptors contribute to the onset of addictive disorders. Combined with data from human and nonhuman primate (not reviewed here), research in this extremely active field has implications both for our understanding of the biology of addiction and for therapeutic interventions to treat the disorder. |
| وصف الملف: | application/pdf |
| تدمد: | 1522-1210 0031-9333 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a5be00eb7ffa6437ba767c70ee387d3Test https://doi.org/10.1152/physrev.00005.2009Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9a5be00eb7ffa6437ba767c70ee387d3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15221210 00319333 |
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