Current state‐of‐the‐art hyperpolarized 13C‐acetate‐to‐acetylcarnitine imaging is not indicative of the altered balance between glucose and fatty acid utilization associated with diabetes
| العنوان: | Current state‐of‐the‐art hyperpolarized 13C‐acetate‐to‐acetylcarnitine imaging is not indicative of the altered balance between glucose and fatty acid utilization associated with diabetes |
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| المؤلفون: | Marion I. Menzel, Ulrich Koellisch, Christoffer Laustsen, Axel Haase, Concetta V. Gringeri, Thomas Stokholm Nørlinger, Jakob Appel Østergaard, Rolf F. Schulte, Allan Flyvbjerg, Hans Stødkilde-Jørgensen |
| المصدر: | Physiological Reports Koellisch, U, Laustsen, C, Nørlinger, T S, Østergaard, J A, Flyvbjerg, A, Gringeri, C V, Menzel, M I, Schulte, R F, Haase, A & Stødkilde-Jørgensen, H 2016, ' Current state-of-the-art hyperpolarized 13C-acetate-to-acetylcarnitine imaging is not indicative of the altered balance between glucose and fatty acid utilization associated with diabetes ', Physiological Reports, vol. 4, no. 17 . https://doi.org/10.14814/phy2.12975Test |
| بيانات النشر: | John Wiley and Sons Inc., 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, Letter, Physiology, Diabetic rat, Acetates, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Dobutamine, Physiology (medical), Diabetes mellitus, Internal medicine, Diabetes Mellitus, Humans, Medicine, Acetylcarnitine, Letters to the Editor, Letter to the Editor, chemistry.chemical_classification, Carbon Isotopes, Kidney, business.industry, Fatty Acids, Hyperpolarized 13c, Fatty acid, Limiting, medicine.disease, Glucose, 030104 developmental biology, medicine.anatomical_structure, Endocrinology, chemistry, business, medicine.drug, Federal state |
| الوصف: | Dear Editor, Indeed acetate trafficking matters, however, hyperpolarized 13C‐acetate‐to‐acetylcarnitine is unable to detect any significant alterations between healthy controls and type‐1 diabetic rat heart, liver, and kidney, respectively in the fed state, with the current clinical setting hyperpolarized methodology. One potential reason for this could be that hyperpolarized MR experiments are in general utilizing superphysiological substrate concentrations and are thus normally considered to perturb the normal physiological conditions. This does however not alter the main conclusion of our study, the inability to differentiate 13C‐acetate‐to‐acetylcarnitine conversion between diabetics and controls, thus limiting the use of the current 13C‐acetate methodology in diabetes patients. It is however noteworthy … |
| اللغة: | English |
| تدمد: | 2051-817X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a942e833ffb74bd9cfec4f9a3759b68Test http://europepmc.org/articles/PMC5027367Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6a942e833ffb74bd9cfec4f9a3759b68 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2051817X |
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