التفاصيل البيبلوغرافية
| العنوان: |
Acute and chronic consequences of polidocanol foam injection in the lung in experimental animals. |
| المؤلفون: |
Grandi, L., Grandi, R. A., Tomasi, C. D., da Rocha, J. L., Cardoso, V., Dal-Pizzol, F. |
| المصدر: |
Phlebology; Dec2013, Vol. 28 Issue 8, p441-444, 4p |
| مصطلحات موضوعية: |
ANALYSIS of variance, ANIMAL experimentation, CHI-squared test, FISHER exact test, HISTOLOGICAL techniques, INFLAMMATION, PULMONARY embolism, RABBITS, RADIONUCLIDE imaging, RESEARCH funding, STATISTICS, DATA analysis, CONTROL groups, DATA analysis software, DESCRIPTIVE statistics |
| مستخلص: |
Objective: To assess the presence of pulmonary embolism and inflammation after polidocanol foam injection into the peripheral veins of rabbits. Method: The animals were treated with polidocanol foam (1 or 3 mg/kg) or vehicle. Early (15 minutes) and late (30 days) animals were evaluated by perfusional lung scintigraphy and histopathological examination. Results: In the control group no alterations were found. After polidocanol foam injection it was observed that an important reduction of pulmonary perfusion in the early periods, was mainly in the left lung (P< 0.001), with consequent embolism in the histological evaluation. In late periods it was observed that the presence of thrombus was with fibrin in small veins, compatible with chronic thrombus and the presence of chronic pulmonary inflammation. Conclusions: The injection of polidocanol foam in experimental animals can induce venous embolism and chronic inflammatory infiltration. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
