Strategies to apply 3Rs in preclinical testing
| العنوان: | Strategies to apply 3Rs in preclinical testing |
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| المؤلفون: | Angeles Rodriguez Basso, Susana Gorzalczany |
| المصدر: | Pharmacology Research & Perspectives Pharmacology Research & Perspectives, Vol 9, Iss 5, Pp n/a-n/a (2021) |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | non clinical, Animal Use Alternatives, Biomedical Research, Computer science, media_common.quotation_subject, Drug Evaluation, Preclinical, reduction, RM1-950, In Vitro Techniques, replacement, Drug Development, Animals, Invited Reviews, refinement, Quality (business), Computer Simulation, General Pharmacology, Toxicology and Pharmaceutics, Animal testing, Drug Approval, media_common, Research Highlights from South America, Alternative methods, Invited Review, South America, testing approaches, Editorial, Neurology, Risk analysis (engineering), Preclinical testing, Non clinical, Therapeutics. Pharmacology |
| الوصف: | Animal experimentation has been fundamental in biological and biomedical research. To guarantee the maximum quality, efficacy and/or safety of products intended for the use in humans in vivo testing is necessary; however, for over 60 years, alternative methods have been developed in response to the necessity to reduce the number of animals used in experimentation, to guarantee their welfare; resorting to animal models only when strictly necessary. The three Rs (Replacement, Reduction, and Refinement), seek to ensure the rational and respectful use of laboratory animals and maintain an adequate projection in terms of bioethical considerations. This article describes different approaches to apply 3Rs in preclinical experimentation for either research or regulatory purposes. 3 Rs testing approaches. |
| تدمد: | 2052-1707 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7837ed4f0ef7cc6fb26b3c1549a8a5a5Test https://pubmed.ncbi.nlm.nih.gov/34609071Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7837ed4f0ef7cc6fb26b3c1549a8a5a5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20521707 |
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