التفاصيل البيبلوغرافية
| العنوان: |
Anti-inflammatory, antiapoptotic, and antioxidant activity of fluoxetine. |
| المؤلفون: |
Caiaffo, Vitor, Oliveira, Belisa D. R., Sá, Fabrício B., Evêncio Neto, Joaquim |
| المصدر: |
Pharmacology Research & Perspectives; Jun2016, Vol. 4 Issue 3, pn/a-N.PAG, 9p |
| مصطلحات موضوعية: |
FLUOXETINE, ANTI-inflammatory agents, ANTIOXIDANTS, THERAPEUTICS, MENTAL depression, HYDROGEN peroxide |
| مستخلص: |
Fluoxetine is a selective serotonin uptake inhibitor that has been widely used to determine the neurotransmission of serotonin in the central nervous system. This substance has emerged as the drug of choice for the treatment of depression due to is safer profile, fewer side effects, and greater tolerability. Studies have found the following important functions of fluoxetine related to the central nervous system: neuroprotection; anti-inflammatory properties similar to standard drugs for the treatment of inflammatory conditions; antioxidant properties, contributing to its therapeutic action and an important intracellular mechanism underlying the protective pharmacological effects seen in clinical practice in the treatment of different stress-related adverse health conditions; and antiapoptotic properties, with greater neuron survival and a reduction in apoptosis mediators as well as oxidative substances, such as superoxide dismutase and hydrogen peroxide. The aim of this study was to perform a review of the literature on the important role of fluoxetine in anti-inflammatory, cell survival, and neuron trophicity mechanisms (antiapoptotic properties) as well as its role regarding enzymes of the antioxidant defense system. [ABSTRACT FROM AUTHOR] |
|
Copyright of Pharmacology Research & Perspectives is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder