نتائج البحث

1

Yin-xing-tong-mai decoction attenuates atherosclerosis via activating PPARγ-LXRα-ABCA1/ABCG1 pathway

المؤلفون: Zhuyuan Fang, Junya Liang, Yizhuo Li, Shasha Zheng, Hong Huang, Ming Liu, Yawei Zheng, Siqi Zhang, Ye Wang

المصدر: Pharmacological research. 169

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfc3b4b2e9f904f0fee5e5a97a1d9e2dTest
https://pubmed.ncbi.nlm.nih.gov/33932607Test

2

Intrauterine growth restriction may reduce hepatic drug metabolism in the early neonatal period

المؤلفون: Jia Yin Soo, Mary J. Berry, I. Caroline McMillen, Janna L. Morrison, Michael D. Wiese

المساهمون: Soo, Jia Yin, Wiese, Michael D, Berry, Mary J, McMillen, I Caroline, Morrison, Janna L

المصدر: Pharmacological Research. 134:68-78

مصطلحات موضوعية: 0301 basic medicine, Drug, congenital, hereditary, and neonatal diseases and abnormalities, CYP2D6, media_common.quotation_subject, Organic Anion Transporters, Intrauterine growth restriction, Physiology, Gestational Age, Gene Expression Regulation, Enzymologic, growth restriction, 03 medical and health sciences, placental restriction, Pregnancy, Gene expression, Animals, Birth Weight, Cytochrome P-450 CYP3A, Medicine, ATP Binding Cassette Transporter, Subfamily B, Member 1, Sheep, Domestic, reproductive and urinary physiology, media_common, Pharmacology, Fetus, Fetal Growth Retardation, postnatal, CYP3A4, business.industry, Gene Expression Regulation, Developmental, fetal, medicine.disease, drug metabolism, female genital diseases and pregnancy complications, 3. Good health, Disease Models, Animal, Low birth weight, 030104 developmental biology, Animals, Newborn, Cytochrome P-450 CYP2D6, Fetal Weight, Liver, Pharmaceutical Preparations, embryonic structures, Female, medicine.symptom, business, Drug metabolism

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0c00e72a1b8d1f6cd3ce874ce832699Test
https://doi.org/10.1016/j.phrs.2018.06.003Test

3

Enhancing PPARγ by HDAC inhibition reduces foam cell formation and atherosclerosis in ApoE deficient mice

المؤلفون: Ai Wei, Ronghui Du, Xingren Chen, Zhiwei Wu, Fang Chen, Wenwen Ding, Qi Gao, Wangsen Cao, Zhiquan Ding

المصدر: Pharmacological research. 160

مصطلحات موضوعية: 0301 basic medicine, Apolipoprotein E, Diet, High-Fat, Hydroxamic Acids, Epigenesis, Genetic, 03 medical and health sciences, Transactivation, Mice, 0302 clinical medicine, Apolipoproteins E, medicine, CCAAT-Enhancer-Binding Protein-alpha, Animals, Foam cell, ATP Binding Cassette Transporter, Subfamily G, Member 1, Pharmacology, Mice, Knockout, biology, Chemistry, Atherosclerosis, Cell biology, Histone Deacetylase Inhibitors, PPAR gamma, 030104 developmental biology, Trichostatin A, RAW 264.7 Cells, ABCG1, 030220 oncology & carcinogenesis, ABCA1, biology.protein, Macrophages, Peritoneal, Histone deacetylase, Signal transduction, medicine.drug, ATP Binding Cassette Transporter 1, Foam Cells

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::522369cd02ffa85a20fc71a57f355461Test
https://pubmed.ncbi.nlm.nih.gov/32621955Test

4

SERCA and P-glycoprotein inhibition and ATP depletion are necessary for celastrol-induced autophagic cell death and collateral sensitivity in multidrug-resistant tumor cells

المؤلفون: David Wei Zhang, Liang Liu, Wei Zhang, Su Wei Xu, Sami Hamdoun, Betty Yuen Kwan Law, Juan Chen, Chenglai Xia, Steven Li Qun Qu, Yoshikazu Sugimoto, Thomas Efferth, An Guo Wu, Simon Wing Fai Mok, Jian Ru Guo, Vincent Kam Wai Wong

المصدر: Pharmacological research. 153

مصطلحات موضوعية: 0301 basic medicine, Programmed cell death, SERCA, Lung Neoplasms, Cell Survival, Antineoplastic Agents, Autophagy-Related Protein 7, Sarcoplasmic Reticulum Calcium-Transporting ATPases, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Adenosine Triphosphate, Cell Line, Tumor, Autophagy, Animals, Humans, ATP Binding Cassette Transporter, Subfamily B, Member 1, P-glycoprotein, Pharmacology, biology, Dose-Response Relationship, Drug, Chemistry, Xenograft Model Antitumor Assays, Drug Resistance, Multiple, Triterpenes, Multiple drug resistance, Mice, Inbred C57BL, 030104 developmental biology, Celastrol, Apoptosis, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Cancer cell, biology.protein, Cancer research, Hepatocytes, Pentacyclic Triterpenes

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df277e2875fecf1636aa92e57c7535ccTest
https://pubmed.ncbi.nlm.nih.gov/31982489Test

5

Brain accumulation of osimertinib and its active metabolite AZ5104 is restricted by ABCB1 (P-glycoprotein) and ABCG2 (breast cancer resistance protein)

المؤلفون: van Hoppe, Stéphanie, Jamalpoor, Amer, Rood, Johannes J M, Wagenaar, Els, Sparidans, Rolf W, Beijnen, Jos H, Schinkel, Alfred H, Afd Pharmacology, Afd Pharmacoepi & Clinical Pharmacology, Pharmacology, Pharmacoepidemiology and Clinical Pharmacology

المساهمون: Afd Pharmacology, Afd Pharmacoepi & Clinical Pharmacology, Pharmacology, Pharmacoepidemiology and Clinical Pharmacology

المصدر: Pharmacological Research, 146. Academic Press Inc.

مصطلحات موضوعية: Male, 0301 basic medicine, Genetically modified mouse, Abcg2, medicine.drug_class, Transgene, ABCG2, Biological Availability, Tyrosine kinase inhibitor, Mice, Transgenic, Biology, Blood–brain barrier, Tyrosine-kinase inhibitor, Cell Line, Madin Darby Canine Kidney Cells, Oral availability, Mice, 03 medical and health sciences, Dogs, 0302 clinical medicine, Brain accumulation, medicine, ATP Binding Cassette Transporter, Subfamily G, Member 2, Animals, Cytochrome P-450 CYP3A, Humans, Tissue Distribution, Osimertinib, ATP Binding Cassette Transporter, Subfamily B, Member 1, Gene knockout, Mice, Knockout, Pharmacology, Acrylamides, Aniline Compounds, Brain, ABCB1, 030104 developmental biology, medicine.anatomical_structure, Blood-Brain Barrier, 030220 oncology & carcinogenesis, Knockout mouse, Cancer research, biology.protein

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b45c32abe93b07c778b9987ddc1cf47fTest
https://doi.org/10.1016/j.phrs.2019.104297Test

6

Terfenadine combined with epirubicin impedes the chemo-resistant human non-small cell lung cancer both in vitro and in vivo through EMT and Notch reversal

المؤلفون: Changli Wang, Hongda Ma, Fan Feng, Qingchun Zhao, Li An, Yan-Hua Fan, Qiao Zhang, Hai-Xiao Chu, Dan-Dan Li, Qi Song

المصدر: Pharmacological Research. 124:105-115

مصطلحات موضوعية: Male, 0301 basic medicine, Epithelial-Mesenchymal Transition, Lung Neoplasms, Combination therapy, Cell Survival, Notch signaling pathway, Antineoplastic Agents, Pharmacology, Metastasis, 03 medical and health sciences, 0302 clinical medicine, Cell Movement, In vivo, Carcinoma, Non-Small-Cell Lung, Antineoplastic Combined Chemotherapy Protocols, Animals, Humans, Medicine, Terfenadine, ATP Binding Cassette Transporter, Subfamily B, Member 1, Lung cancer, Epirubicin, Cisplatin, Mice, Inbred BALB C, Wound Healing, Receptors, Notch, business.industry, medicine.disease, Tumor Burden, 030104 developmental biology, A549 Cells, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, business, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::302509cf749e234f3d1ba5b6434a967bTest
https://doi.org/10.1016/j.phrs.2017.07.021Test

7

P-gp/ABCB1 exerts differential impacts on brain and fetal exposure to norbuprenorphine

المؤلفون: Laura M. Shireman, Linda J. Risler, Naveen K. Neradugomma, Bhagwat Prasad, Michael Z. Liao, Prachi Choudhari, Danny D. Shen, Qingcheng Mao, Brian Phillips, Chunying Gao

المصدر: Pharmacological Research. 119:61-71

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Narcotic Antagonists, Metabolite, Pharmacology, 030226 pharmacology & pharmacy, Article, Gene Knockout Techniques, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Pregnancy, Internal medicine, Placenta, medicine, ATP Binding Cassette Transporter, Subfamily G, Member 2, Animals, Tissue Distribution, ATP Binding Cassette Transporter, Subfamily B, Member 1, Norbuprenorphine, Respiratory system, Maternal-Fetal Exchange, Active metabolite, Mice, Knockout, Fetus, Brain, Buprenorphine, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, chemistry, Blood-Brain Barrier, Maternal Exposure, embryonic structures, Gestation, Female, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af95123d714b1ea4be7abca1bcd07624Test
https://doi.org/10.1016/j.phrs.2017.01.018Test

8

Rev-erbα activation down-regulates hepatic Pck1 enzyme to lower plasma glucose in mice

المؤلفون: Baojian Wu, Dong Dong, Xue Yuan, Zhijie Li

المصدر: Pharmacological research. 141

مصطلحات موضوعية: 0301 basic medicine, Blood Glucose, Male, medicine.medical_specialty, Pyrrolidines, Fructose 1,6-bisphosphatase, Down-Regulation, Thiophenes, Diabetes Mellitus, Experimental, 03 medical and health sciences, Mice, 0302 clinical medicine, PCK1, Internal medicine, PCK2, Cell Line, Tumor, medicine, Glucose homeostasis, Animals, Humans, Hypoglycemic Agents, Glycolysis, Pharmacology, biology, Chemistry, Intracellular Signaling Peptides and Proteins, Hep G2 Cells, Pyruvate carboxylase, Mice, Inbred C57BL, 030104 developmental biology, Endocrinology, Gluconeogenesis, 030220 oncology & carcinogenesis, Nuclear Receptor Subfamily 1, Group D, Member 1, biology.protein, Phosphoenolpyruvate Carboxykinase (GTP), Phosphofructokinase

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4c290aa1af188baf20324ce66580216Test
https://pubmed.ncbi.nlm.nih.gov/30639375Test

9

P-gp/ABCB1 exerts differential impacts on brain and fetal exposure to norbuprenorphine—Significance of zeitgeber time on pharmacokinetics

المؤلفون: Ranjeet Prasad Dash, Rana Rais

المصدر: Pharmacological Research. 121:251-252

مصطلحات موضوعية: 0301 basic medicine, Pharmacology, business.industry, Brain, Fetal exposure, Buprenorphine, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, chemistry, Pharmacokinetics, Zeitgeber, Animals, Humans, Medicine, ATP Binding Cassette Transporter, Subfamily B, Member 1, Norbuprenorphine, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15819289a49dd21af1f632fc522abab0Test
https://doi.org/10.1016/j.phrs.2017.04.004Test

10

P-gp/ABCB1 exerts differential impacts on brain and fetal exposure to norbuprenorphine—Response to ‘Letter to the Editor’

المؤلفون: Danny D. Shen, Michael Z. Liao, Qingcheng Mao

المصدر: Pharmacological Research. 121:253

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::597204ab2804b4230b8476f4d70dcdc6Test
https://doi.org/10.1016/j.phrs.2017.04.007Test

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