Ginsenoside from ginseng: a promising treatment for inflammatory bowel disease
| العنوان: | Ginsenoside from ginseng: a promising treatment for inflammatory bowel disease |
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| المؤلفون: | Zeng-Ping Kang, Youbao Zhonga, Duan-Yong Liu, Hai-Mei Zhao, Tiantian Wu, Jia-Qi Huang |
| المصدر: | Pharmacological Reports |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Ginsenosides, Anti-Inflammatory Agents, Panax, Review, Inflammatory bowel disease, Pathogenesis, chemistry.chemical_compound, Ginseng, Pharmacological effects, Immune system, medicine, Animals, Humans, Receptor, Pharmacology, Autoimmune disease, business.industry, Immune cells, General Medicine, Inflammatory Bowel Diseases, medicine.disease, chemistry, Ginsenoside, Immunology, Cytokines, Immune disorder, business |
| الوصف: | Inflammatory bowel disease (IBD) is an autoimmune disease mediated by immune disorder and termed as one of the most refractory diseases by the Word Health Organization. Its morbidity has increased steadily over the past half century worldwide. Environmental, genetic, infectious, and immune factors are integral to the pathogenesis of IBD. Commonly known as the king of herbs, ginseng has been consumed in many countries for the past 2000 years. Its active ingredient ginsenosides, as the most prominent saponins of ginseng, have a wide range of pharmacological effects. Recent studies have confirmed that the active components of Panax ginseng have anti-inflammatory and immunomodulatory effects on IBD, including regulating the balance of immune cells, inhibiting the expression of cytokines, as well as activating Toll-like receptor 4, Nuclear factor-kappa B (NF-κB), nucleotide-binding oligomerization domain-like receptor (NLRP), mitogen-activated protein kinase signaling, and so on. Accumulated evidence indicates that ginsenosides may serve as a potential novel therapeutic drug or health product additive in IBD prevention and treatment in the future. |
| تدمد: | 2299-5684 1734-1140 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa3d0b2ef1cdcbf8b18e5c3807fc1626Test https://doi.org/10.1007/s43440-020-00213-zTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fa3d0b2ef1cdcbf8b18e5c3807fc1626 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22995684 17341140 |
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