دورية
Time and Cost of Hospitalisation for Salvage Therapy in Adults with Philadelphia Chromosome-Negative B Cell Precursor Relapsed or Refractory Acute Lymphoblastic Leukaemia in Spain
| العنوان: | Time and Cost of Hospitalisation for Salvage Therapy in Adults with Philadelphia Chromosome-Negative B Cell Precursor Relapsed or Refractory Acute Lymphoblastic Leukaemia in Spain |
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| المؤلفون: | Boluda, Blanca, Rodríguez-Veiga, Rebeca, Martínez-Cuadrón, David, Lorenzo, Ignacio, Sanz, Jaime, Regadera, Ana, Sempere, Amparo, Senent, Leonor, Cervera, Jose, Solves, Pilar, Reitan, John, Gea, Salvador, Sanz, Miguel, Montesinos, Pau |
| المصدر: | PharmacoEconomics - Open; June 2019, Vol. 3 Issue: 2 p229-235, 7p |
| مستخلص: | Philadelphia chromosome-negative (Ph−) relapsed or refractory (R/R) B-cell precursor acute lymphoblastic leukaemia (ALL) is rare, and information on its impact on healthcare systems is scarce. To quantify the time and reimbursement associated with hospitalisations of patients with R/R ALL in a Spanish hospital. Retrospective review of medical charts identified patients aged ≥ 18 years with Ph− R/R ALL hospitalised between 1998 and 2014. Data were collected from the date of first diagnosis of R/R ALL (index) until death or loss to follow-up. The primary endpoint was the proportion of time hospitalised during chemotherapy. Reimbursement associated with hospitalisations (including associated chemotherapy) was also assessed. Thirty-two patients were eligible for inclusion. Their median age was 41 years, and 50% had a first remission duration of ≤ 1 year; 34% had undergone allogeneic haematological stem-cell transplantation (alloHSCT). Overall, 31 patients had received intensive salvage chemotherapy, during which there were 42 hospitalisations (mean 1.4/patient; mean duration 26 days). Patients spent a mean of 71% of the chemotherapy period in hospital. Total mean reimbursement was €26,417 per patient, almost all (€25,723) attributable to inpatient stays (€18,986/hospitalisation). From the index date to death or loss to follow-up (excluding alloHSCT-related hospitalisations), there were 80 hospitalisations (mean duration 24 days); mean reimbursement was €16,692 per hospitalisation and €41,730 per patient. AlloHSCT (n= 8) involved 18 hospitalisations (mean reimbursement €39,782/hospitalisation; €89,510/patient). Data from this sample of patients suggest that hospitalisations in R/R ALL are lengthy and associated with high costs in Spain. |
| قاعدة البيانات: | Supplemental Index |
Full Text Finder | تدمد: | 25094262 25094254 |
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| DOI: | 10.1007/s41669-018-0098-8 |