Interactions with Microbial Proteins Driving the Antibacterial Activity of Flavonoids
| العنوان: | Interactions with Microbial Proteins Driving the Antibacterial Activity of Flavonoids |
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| المؤلفون: | Fabrizio Dal Piaz, Viviana Izzo, Valentina Parisi, Nunziatina De Tommasi, Francesca Mensitieri, Giuliana Donadio, Maria Laura Bellone, Valentina Santoro |
| المصدر: | Pharmaceutics Pharmaceutics, Vol 13, Iss 660, p 660 (2021) |
| بيانات النشر: | MDPI, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | efflux pumps, enzyme inhibitor, Pharmaceutical Science, Review, Bacterial protein, 03 medical and health sciences, Pharmacy and materia medica, Antibiotic resistance, antibacterial activity, ATP synthetase, antibiofilm activity, 030304 developmental biology, 0303 health sciences, biology, bioactive natural compounds, 030306 microbiology, Chemistry, fungi, food and beverages, DNA gyrase, Antimicrobial, biology.organism_classification, Structural heterogeneity, RS1-441, Biochemistry, flavonoids, Molecular targets, Efflux, Antibacterial activity, Bacteria |
| الوصف: | Flavonoids are among the most abundant natural bioactive compounds produced by plants. Many different activities have been reported for these secondary metabolites against numerous cells and systems. One of the most interesting is certainly the antimicrobial, which is stimulated through various molecular mechanisms. In fact, flavonoids are effective both in directly damaging the envelope of Gram-negative and Gram-positive bacteria but also by acting toward specific molecular targets essential for the survival of these microorganisms. The purpose of this paper is to present an overview of the most interesting results obtained in the research focused on the study of the interactions between flavonoids and bacterial proteins. Despite the great structural heterogeneity of these plant metabolites, it is interesting to observe that many flavonoids affect the same cellular pathways. Furthermore, it is evident that some of these compounds interact with more than one target, producing multiple effects. Taken together, the reported data demonstrate the great potential of flavonoids in developing innovative systems, which can help address the increasingly serious problem of antibiotic resistance. |
| اللغة: | English |
| تدمد: | 1999-4923 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b261abff496127a80fd35281d9b66342Test http://europepmc.org/articles/PMC8147964Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b261abff496127a80fd35281d9b66342 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19994923 |
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