التفاصيل البيبلوغرافية
| العنوان: |
Novel Therapies to Address Unmet Needs in ITP. |
| المؤلفون: |
Mingot-Castellano, María Eva1 (AUTHOR) mariae.mingot.sspa@juntadeandalucia.es, Bastida, José María2 (AUTHOR) jmbastida@saludcastillayleon.es, Caballero-Navarro, Gonzalo3 (AUTHOR) gcaballeron@salud.aragon.es, Entrena Ureña, Laura4 (AUTHOR) laura_eu@hotmail.com, González-López, Tomás José5 (AUTHOR) tjgonzalez@saludcastillayleon.es, González-Porras, José Ramón2 (AUTHOR) jrgp@usal.es, Butta, Nora6 (AUTHOR) nbutta@hotmail.com, Canaro, Mariana7 (AUTHOR) mcanaro@gmail.com, Jiménez-Bárcenas, Reyes8 (AUTHOR) rejimbar@hotmail.com, Gómez del Castillo Solano, María del Carmen9 (AUTHOR) ma.del.carmen.gomez.del.castillo.solano@sergas.es, Sánchez-González, Blanca10 (AUTHOR) bsanchezgonzalez@hospitaldelmar.cat, Pascual-Izquierdo, Cristina11 (AUTHOR) crisizquierdo3@yahoo.es |
| المصدر: |
Pharmaceuticals (14248247). Jul2022, Vol. 15 Issue 7, pN.PAG-N.PAG. 24p. |
| مصطلحات موضوعية: |
*IDIOPATHIC thrombocytopenic purpura, *COMPLEMENT activation, *RITUXIMAB, *PLATELET count, *THROMBOPOIETIN, *AUTOIMMUNE diseases, *BLOOD platelets, *BLOOD platelet aggregation |
| مستخلص: |
Primary immune thrombocytopenia (ITP) is an autoimmune disorder that causes low platelet counts and subsequent bleeding risk. Although current corticosteroid-based ITP therapies are able to improve platelet counts, up to 70% of subjects with an ITP diagnosis do not achieve a sustained clinical response in the absence of treatment, thus requiring a second-line therapy option as well as additional care to prevent bleeding. Less than 40% of patients treated with thrombopoietin analogs, 60% of those treated with splenectomy, and 20% or fewer of those treated with rituximab or fostamatinib reach sustained remission in the absence of treatment. Therefore, optimizing therapeutic options for ITP management is mandatory. The pathophysiology of ITP is complex and involves several mechanisms that are apparently unrelated. These include the clearance of autoantibody-coated platelets by splenic macrophages or by the complement system, hepatic desialylated platelet destruction, and the inhibition of platelet production from megakaryocytes. The number of pathways involved may challenge treatment, but, at the same time, offer the possibility of unveiling a variety of new targets as the knowledge of the involved mechanisms progresses. The aim of this work, after revising the limitations of the current treatments, is to perform a thorough review of the mechanisms of action, pharmacokinetics/pharmacodynamics, efficacy, safety, and development stage of the novel ITP therapies under investigation. Hopefully, several of the options included herein may allow us to personalize ITP management according to the needs of each patient in the near future. [ABSTRACT FROM AUTHOR] |
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