دورية أكاديمية
A Safe-by-Design Approach for the Synthesis of a Novel Cross-Linked Hyaluronic Acid with Improved Biological and Physical Properties
| العنوان: | A Safe-by-Design Approach for the Synthesis of a Novel Cross-Linked Hyaluronic Acid with Improved Biological and Physical Properties |
|---|---|
| المؤلفون: | Sabrina Sciabica, Riccardo Barbari, Riccardo Fontana, Giovanni Tafuro, Alessandra Semenzato, Daniela Traini, Dina M. Silva, Larissa Gomes Dos Reis, Luisa Canilli, Massimo Terno, Peggy Marconi, Anna Baldisserotto, Silvia Vertuani, Stefano Manfredini |
| المصدر: | Pharmaceuticals, Vol 16, Iss 3, p 431 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine LCC:Pharmacy and materia medica |
| مصطلحات موضوعية: | hyaluronic acid, arginine, cross-linking, bioactivity, cosmeceutical, skin, Medicine, Pharmacy and materia medica, RS1-441 |
| الوصف: | Hyaluronic acid (HA) is a polymer with unique biological properties that has gained in interest over the years, with applications in pharmaceutical, cosmetic, and biomedical fields; however, its widespread use has been limited by its short half-life. Therefore, a new cross-linked hyaluronic acid was designed and characterized using a natural and safe cross-linking agent, such as arginine methyl ester, which provided improved resistance to enzymatic action, as compared to the corresponding linear polymer. The antibacterial profile of the new derivative was shown to be effective against S. aureus and P. acnes, making it a promising candidate for use in cosmetic formulations and skin applications. Its effect on S. pneumoniae, combined with its excellent tolerability profile on lung cells, also makes this new product suitable for applications involving the respiratory tract. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1424-8247 |
| العلاقة: | https://www.mdpi.com/1424-8247/16/3/431Test; https://doaj.org/toc/1424-8247Test |
| DOI: | 10.3390/ph16030431 |
| الوصول الحر: | https://doaj.org/article/870626f7ea4640d3bb15adadc252685eTest |
| رقم الانضمام: | edsdoj.870626f7ea4640d3bb15adadc252685e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14248247 |
|---|---|
| DOI: | 10.3390/ph16030431 |